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Tmem145 transmembrane protein 145 [ Mus musculus (house mouse) ]

Gene ID: 330485, updated on 27-Nov-2024

Summary

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Official Symbol
Tmem145provided by MGI
Official Full Name
transmembrane protein 145provided by MGI
Primary source
MGI:MGI:3607779
See related
Ensembl:ENSMUSG00000043843 AllianceGenome:MGI:3607779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B930076A02Rik
Summary
Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human TMEM145 (transmembrane protein 145). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 48.9), CNS E18 (RPKM 39.9) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem145 in Genome Data Viewer
Location:
7 A3; 7 13.74 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25004981..25015621)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25305500..25316196)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene platelet-activating factor acetylhydrolase, isoform 1b, subunit 3 Neighboring gene STARR-seq mESC enhancer starr_18300 Neighboring gene proline rich 19 Neighboring gene multiple EGF-like-domains 8 Neighboring gene cornifelin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Potter PK, et al. Nat Commun, 2016 Aug 18. PMID 27534441, Free PMC Article
  2. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
  3. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • B930076A02Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in response to pheromone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 145

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403202.1 → NP_001390131.1  transmembrane protein 145 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC156992
    UniProtKB/TrEMBL
    A0A5F8MPQ2
    Related
    ENSMUSP00000159059.2, ENSMUST00000205639.3

  2. NM_001403203.1 → NP_001390132.1  transmembrane protein 145 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC156992
    UniProtKB/TrEMBL
    E9PUE6

  3. NM_183311.3 → NP_899134.2  transmembrane protein 145 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC156992
    Consensus CDS
    CCDS39837.1
    UniProtKB/TrEMBL
    D3YU53, E9PUE6
    Related
    ENSMUSP00000104046.2, ENSMUST00000108409.2
    Conserved Domains (1) summary
    pfam10192
    Location:157 → 411
    GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

RNA

  1. NR_175362.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156992

  2. NR_175363.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156992

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    25004981..25015621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540114.3 → XP_006540177.1  transmembrane protein 145 isoform X1

    UniProtKB/TrEMBL
    A0A5F8MPQ2
    Conserved Domains (2) summary
    PHA03247
    Location:476 → 599
    PHA03247; large tegument protein UL36; Provisional
    pfam10192
    Location:157 → 411
    GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

  2. XM_030242692.2 → XP_030098552.1  transmembrane protein 145 isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:179 → 302
    PHA03247; large tegument protein UL36; Provisional
    cl21735
    Location:1 → 114
    Lung_7-TM_R; Lung seven transmembrane receptor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C4U2.1 GenPept UniProtKB/Swiss-Prot:Q8C4U2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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