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Fbxo41 F-box protein 41 [ Mus musculus (house mouse) ]

Gene ID: 330369, updated on 27-Nov-2024

Summary

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Official Symbol
Fbxo41provided by MGI
Official Full Name
F-box protein 41provided by MGI
Primary source
MGI:MGI:1261912
See related
Ensembl:ENSMUSG00000047013 AllianceGenome:MGI:1261912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9630017H13; D6Ertd538e
Summary
Is expressed in several structures, including forelimb bud; male reproductive gland or organ; nervous system; notochord; and sensory organ. Orthologous to human FBXO41 (F-box protein 41). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 14.6), frontal lobe adult (RPKM 13.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxo41 in Genome Data Viewer
Location:
6 C3; 6 37.48 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85446556..85479976, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85469574..85502994, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 5 Neighboring gene protease-associated domain containing 1 Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene early growth response 4 Neighboring gene ALMS1, centrosome and basal body associated Neighboring gene STARR-seq mESC enhancer starr_16505 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation. Quadros ARAA, et al. iScience, 2022 Apr 15. PMID 35372812, Free PMC Article
  2. Fbxo41 Promotes Disassembly of Neuronal Primary Cilia. King CR, et al. Sci Rep, 2019 Jun 3. PMID 31160656, Free PMC Article
  3. Loss of the neuron-specific F-box protein FBXO41 models an ataxia-like phenotype in mice with neuronal migration defects and degeneration in the cerebellum. Mukherjee C, et al. J Neurosci, 2015 Jun 10. PMID 26063905, Free PMC Article
  4. Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry. Del Mar Masdeu M, et al. Oncotarget, 2017 Nov 24. PMID 29254152, Free PMC Article
  5. Global gene expression analysis of murine limb development. Taher L, et al. PLoS One, 2011. PMID 22174793, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.
    Title: Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dentate gyrus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
F-box only protein 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001160.3 → NP_001001160.1  F-box only protein 41

    See identical proteins and their annotated locations for NP_001001160.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK147230, BC070445, CD774837
    Consensus CDS
    CCDS20296.1
    UniProtKB/Swiss-Prot
    Q6NS60, Q6P7W4, Q6ZPG1
    UniProtKB/TrEMBL
    Q3UGY7
    Related
    ENSMUSP00000124524.2, ENSMUST00000161078.8
    Conserved Domains (5) summary
    TIGR02473
    Location:216 → 348
    flagell_FliJ; flagellar export protein FliJ
    sd00017
    Location:10 → 33
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00034
    Location:657 → 683
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:555 → 593
    F-box-like; F-box-like
    pfam16515
    Location:237 → 299
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

  2. NM_001289674.1 → NP_001276603.1  F-box only protein 41

    See identical proteins and their annotated locations for NP_001276603.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks an exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK147230, BC070445, CD774837
    Consensus CDS
    CCDS20296.1
    UniProtKB/Swiss-Prot
    Q6NS60, Q6P7W4, Q6ZPG1
    UniProtKB/TrEMBL
    Q3UGY7
    Related
    ENSMUSP00000125671.2, ENSMUST00000159062.8
    Conserved Domains (5) summary
    TIGR02473
    Location:216 → 348
    flagell_FliJ; flagellar export protein FliJ
    sd00017
    Location:10 → 33
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00034
    Location:657 → 683
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:555 → 593
    F-box-like; F-box-like
    pfam16515
    Location:237 → 299
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

  3. NM_001289675.1 → NP_001276604.1  F-box only protein 41

    See identical proteins and their annotated locations for NP_001276604.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK147230, AK147681, BC070445, CD774837
    Consensus CDS
    CCDS20296.1
    UniProtKB/Swiss-Prot
    Q6NS60, Q6P7W4, Q6ZPG1
    UniProtKB/TrEMBL
    Q3UGY7
    Related
    ENSMUSP00000124754.2, ENSMUST00000161546.2
    Conserved Domains (5) summary
    TIGR02473
    Location:216 → 348
    flagell_FliJ; flagellar export protein FliJ
    sd00017
    Location:10 → 33
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00034
    Location:657 → 683
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:555 → 593
    F-box-like; F-box-like
    pfam16515
    Location:237 → 299
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    85446556..85479976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NS60.3 GenPept UniProtKB/Swiss-Prot:Q6NS60

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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