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Abcd3 ATP binding cassette subfamily D member 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32992, updated on 9-Dec-2024

Summary

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Official Symbol
Abcd3provided by FlyBase
Official Full Name
ATP binding cassette subfamily D member 3provided by FlyBase
Primary source
FLYBASE:FBgn0031069
Locus tag
Dmel_CG12703
See related
AllianceGenome:FB:FBgn0031069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ABCD; ABCD3; CG12703; DmCG12703; Dmel\CG12703; i17; Pmp70; PMP70
Summary
Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and long-chain fatty acid transmembrane transporter activity. Predicted to be involved in fatty acid catabolic process; long-chain fatty acid import into peroxisome; and peroxisome organization. Predicted to be located in membrane. Predicted to be active in peroxisomal membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Zellweger syndrome and congenital bile acid synthesis defect 5. Orthologous to human ABCD3 (ATP binding cassette subfamily D member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Abcd3 in Genome Data Viewer
Location:
18F1-18F1; 1-64 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19750770..19759280)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19644803..19653313)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45501 Neighboring gene parvin Neighboring gene Augmenter of liver regeneration Neighboring gene uncharacterized protein Neighboring gene zelda Neighboring gene long non-coding RNA:CR44885

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy. Jo DS, et al. Autophagy, 2020 Nov. PMID 31964216, Free PMC Article
  2. Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes. Nakayama M, et al. PLoS One, 2011. PMID 21826223, Free PMC Article
  3. Dietary Stimuli, Intestinal Bacteria and Peptide Hormones Regulate Female Drosophila Defecation Rate. Kotronarou K, et al. Metabolites, 2023 Feb 12. PMID 36837883, Free PMC Article
  4. Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity. Bolukbasi E, et al. Cell Rep, 2017 Oct 17. PMID 29045833, Free PMC Article
  5. Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation. Meiklejohn CD, et al. PLoS Biol, 2011 Aug. PMID 21857805, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid import into peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peroxisome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in very long-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
ATP binding cassette subfamily D member 3
Names
Abcd3-PA
Abcd3-PB
Abcd3-PC
Abcd3-PD
CG12703-PA
CG12703-PB
CG12703-PC
CG12703-PD
Pmp70
peroxisomal membrane protein 70 kDa
NP_001259732.1
NP_001259733.1
NP_001259734.1
NP_608354.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19750770..19759280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272805.1 → NP_001259734.1  ATP binding cassette subfamily D member 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259734.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWC8
    Conserved Domains (3) summary
    cd03223
    Location:446 → 651
    ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
    TIGR00954
    Location:3 → 653
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
    pfam06472
    Location:63 → 342
    ABC_membrane_2; ABC transporter transmembrane region 2

  2. NM_134510.2 → NP_608354.1  ATP binding cassette subfamily D member 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608354.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWC8
    Related
    FBpp0074564
    Conserved Domains (3) summary
    cd03223
    Location:446 → 651
    ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
    TIGR00954
    Location:3 → 653
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
    pfam06472
    Location:63 → 342
    ABC_membrane_2; ABC transporter transmembrane region 2

  3. NM_001272803.1 → NP_001259732.1  ATP binding cassette subfamily D member 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259732.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWC8
    Conserved Domains (3) summary
    cd03223
    Location:446 → 651
    ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
    TIGR00954
    Location:3 → 653
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
    pfam06472
    Location:63 → 342
    ABC_membrane_2; ABC transporter transmembrane region 2

  4. NM_001272804.1 → NP_001259733.1  ATP binding cassette subfamily D member 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259733.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF96
    Conserved Domains (3) summary
    cd03223
    Location:422 → 627
    ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
    TIGR00954
    Location:11 → 629
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
    pfam06472
    Location:39 → 318
    ABC_membrane_2; ABC transporter transmembrane region 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PF96 M9PF96
Q9VWC8 Q9VWC8

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