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CG12531 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32986, updated on 9-Dec-2024

Summary

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Official Symbol
CG12531provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031064
Locus tag
Dmel_CG12531
See related
AllianceGenome:FB:FBgn0031064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12531
Summary
Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to human SLC7A14 (solute carrier family 7 member 14). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG12531 in Genome Data Viewer
Location:
18E3-18E4; 1-64 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19718923..19730199)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19612956..19624232)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene meso18E Neighboring gene long non-coding RNA:CR44889 Neighboring gene Adaptor Protein complex 1/2, beta subunit Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metabolite transport across the mammalian and insect brain diffusion barriers. Weiler A, et al. Neurobiol Dis, 2017 Nov. PMID 28237316
  2. A post-ingestive amino acid sensor promotes food consumption in Drosophila. Yang Z, et al. Cell Res, 2018 Oct. PMID 30209352, Free PMC Article
  3. Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa. Lehmann M, et al. Methods Mol Biol, 2019. PMID 30324448
  4. A screen for neurotransmitter transporters expressed in the visual system of Drosophila melanogaster identifies three novel genes. Romero-Calderón R, et al. Dev Neurobiol, 2007 Apr. PMID 17443808
  5. Computation-based discovery of related transcriptional regulatory modules and motifs using an experimentally validated combinatorial model. Halfon MS, et al. Genome Res, 2002 Jul. PMID 12097338, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12531-PA
CG12531-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19718923..19730199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134506.3 → NP_608350.2  uncharacterized protein Dmel_CG12531, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608350.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G7H832, Q9VWD3
    Conserved Domains (2) summary
    TIGR00906
    Location:52 → 679
    2A0303; cationic amino acid transport permease
    pfam13906
    Location:629 → 679
    AA_permease_C; C-terminus of AA_permease

  2. NM_001272799.1 → NP_001259728.1  uncharacterized protein Dmel_CG12531, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259728.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G7H832, M9PHM0
    Conserved Domains (2) summary
    TIGR00906
    Location:52 → 679
    2A0303; cationic amino acid transport permease
    pfam13906
    Location:629 → 679
    AA_permease_C; C-terminus of AA_permease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PHM0 M9PHM0
Q9VWD3 Q9VWD3

Gene LinkOut

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