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Dennd2c DENN domain containing 2C [ Mus musculus (house mouse) ]

Gene ID: 329727, updated on 27-Nov-2024

Summary

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Official Symbol
Dennd2cprovided by MGI
Official Full Name
DENN domain containing 2Cprovided by MGI
Primary source
MGI:MGI:3036254
See related
Ensembl:ENSMUSG00000007379 AllianceGenome:MGI:3036254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930010I20Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in nucleoplasm. Is expressed in several structures, including foregut; liver; male reproductive gland or organ; pharyngo-tympanic tube; and skin. Orthologous to human DENND2C (DENN domain containing 2C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14 (RPKM 3.1), liver E14.5 (RPKM 2.9) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Dennd2c in Genome Data Viewer
Location:
3 F2.2; 3 45.25 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (103009954..103077054)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (103102647..103169738)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08584 Neighboring gene neuroblastoma ras oncogene Neighboring gene STARR-seq mESC enhancer starr_08585 Neighboring gene adenosine monophosphate deaminase 1 Neighboring gene STARR-seq mESC enhancer starr_08586 Neighboring gene STARR-seq mESC enhancer starr_08590 Neighboring gene STARR-seq mESC enhancer starr_08592 Neighboring gene STARR-positive B cell enhancer mm9_chr3:102975364-102975665 Neighboring gene BCAS2 pre-mRNA processing factor Neighboring gene STARR-seq mESC enhancer starr_08594 Neighboring gene predicted gene, 40113

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DENN domain proteins: regulators of Rab GTPases. Marat AL, et al. J Biol Chem, 2011 Apr 22. PMID 21330364, Free PMC Article
  2. Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons. Del Villar K, et al. Proc Natl Acad Sci U S A, 2004 Mar 23. PMID 15007167, Free PMC Article
  3. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article
  4. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 2C
Names
DENN/MADD domain containing 2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356383.1 → NP_001343312.1  DENN domain-containing protein 2C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC150894, BC060666
    Related
    ENSMUST00000173037.8
    Conserved Domains (3) summary
    smart00801
    Location:365 → 431
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:39 → 126
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:136 → 320
    DENN; DENN (AEX-3) domain

  2. NM_001384113.1 → NP_001371042.1  DENN domain-containing protein 2C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC150894
    UniProtKB/Swiss-Prot
    Q3T9X2, Q3UV30, Q6P9P8, Q80V46
    UniProtKB/TrEMBL
    E9Q4E4
    Related
    ENSMUSP00000134008.2, ENSMUST00000173206.8
    Conserved Domains (3) summary
    smart00801
    Location:807 → 873
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:481 → 568
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:578 → 762
    DENN; DENN (AEX-3) domain

  3. NM_177857.2 → NP_808525.2  DENN domain-containing protein 2C isoform 1

    See identical proteins and their annotated locations for NP_808525.2

    Status: VALIDATED

    Source sequence(s)
    BC060666
    Consensus CDS
    CCDS38572.2
    UniProtKB/Swiss-Prot
    Q3T9X2, Q3UV30, Q6P9P8, Q80V46
    UniProtKB/TrEMBL
    E9Q4E4
    Related
    ENSMUSP00000127187.3, ENSMUST00000172288.3
    Conserved Domains (3) summary
    smart00801
    Location:807 → 873
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:481 → 568
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:578 → 762
    DENN; DENN (AEX-3) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    103009954..103077054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501605.5 → XP_006501668.1  DENN domain-containing protein 2C isoform X2

    UniProtKB/Swiss-Prot
    Q3T9X2, Q3UV30, Q6P9P8, Q80V46
    Conserved Domains (3) summary
    smart00801
    Location:793 → 859
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:481 → 568
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:578 → 754
    DENN; DENN (AEX-3) domain

  2. XM_006501604.3 → XP_006501667.1  DENN domain-containing protein 2C isoform X1

    See identical proteins and their annotated locations for XP_006501667.1

    UniProtKB/Swiss-Prot
    Q3T9X2, Q3UV30, Q6P9P8, Q80V46
    UniProtKB/TrEMBL
    E9Q4E4
    Conserved Domains (3) summary
    smart00801
    Location:807 → 873
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:481 → 568
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:578 → 762
    DENN; DENN (AEX-3) domain

  3. XM_030252655.2 → XP_030108515.1  DENN domain-containing protein 2C isoform X1

    UniProtKB/Swiss-Prot
    Q3T9X2, Q3UV30, Q6P9P8, Q80V46
    UniProtKB/TrEMBL
    E9Q4E4
    Conserved Domains (3) summary
    smart00801
    Location:807 → 873
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:481 → 568
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:578 → 762
    DENN; DENN (AEX-3) domain

  4. XM_006501602.4 → XP_006501665.1  DENN domain-containing protein 2C isoform X1

    See identical proteins and their annotated locations for XP_006501665.1

    UniProtKB/Swiss-Prot
    Q3T9X2, Q3UV30, Q6P9P8, Q80V46
    UniProtKB/TrEMBL
    E9Q4E4
    Conserved Domains (3) summary
    smart00801
    Location:807 → 873
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:481 → 568
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:578 → 762
    DENN; DENN (AEX-3) domain

RNA

  1. XR_004941337.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9P8.1 GenPept UniProtKB/Swiss-Prot:Q6P9P8

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