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Arp10 Actin-related protein 10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32969, updated on 4-Jan-2025

Summary

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Official Symbol
Arp10provided by FlyBase
Official Full Name
Actin-related protein 10provided by FlyBase
Primary source
FLYBASE:FBgn0031050
Locus tag
Dmel_CG12235
See related
AllianceGenome:FB:FBgn0031050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Arp11; ARP11; CG12235; Dmel\CG12235
Summary
Involved in microtubule-based movement. Predicted to be part of dynactin complex. Is expressed in adult head and adult heart. Orthologous to human ACTR10 (actin related protein 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Arp10 in Genome Data Viewer
Location:
18D12-18D12; 1-63 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19644531..19646176, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19538564..19540209, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sec61 gamma subunit Neighboring gene Ranbp21 Neighboring gene elys

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Burst of Genetic Innovation in Drosophila Actin-Related Proteins for Testis-Specific Function. Schroeder CM, et al. Mol Biol Evol, 2020 Mar 1. PMID 31697328, Free PMC Article
  2. Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein. Hammesfahr B, et al. BMC Evol Biol, 2012 Jun 22. PMID 22726940, Free PMC Article
  3. The diaphanous gene of Drosophila interacts antagonistically with multiple wing hairs and plays a key role in wing hair morphogenesis. Lu Q, et al. PLoS One, 2015. PMID 25730111, Free PMC Article
  4. Multiple classes of MSL binding sites target dosage compensation to the X chromosome of Drosophila. Oh H, et al. Curr Biol, 2004 Mar 23. PMID 15043812
  5. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. Eckley DM, et al. Mol Biol Cell, 2003 Jul. PMID 12857853, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional assay for CG12235: Arp11 significantly decreases formation of organized Arp1 assemblies in cultured cells.
    Title: Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in microtubule-based movement IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde axonal transport of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynactin complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Actin-related protein 10
Names
Arp10-PA
Arp10-PB
Arp11
CG12235-PA
CG12235-PB
actin related protein 11

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19644531..19646176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298523.1 → NP_001285452.1  Actin-related protein 10, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285452.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWE8
    Conserved Domains (2) summary
    smart00268
    Location:11 → 340
    ACTIN; Actin
    cl17037
    Location:12 → 367
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. NM_134494.3 → NP_608338.1  Actin-related protein 10, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608338.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWE8
    Related
    FBpp0074529
    Conserved Domains (2) summary
    smart00268
    Location:11 → 340
    ACTIN; Actin
    cl17037
    Location:12 → 367
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWE8 Q9VWE8

Gene LinkOut

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