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Rcd-1 Required for cell differentiation 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32966, updated on 9-Dec-2024

Summary

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Official Symbol
Rcd-1provided by FlyBase
Official Full Name
Required for cell differentiation 1provided by FlyBase
Primary source
FLYBASE:FBgn0031047
Locus tag
Dmel_CG14213
See related
AllianceGenome:FB:FBgn0031047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Caf40; CAF40; CG14213; CNOT9; Dmel\CG14213; Drcd-1; Rcd1
Summary
Involved in mRNA catabolic process and negative regulation of translation. Part of CCR4-NOT complex. Is expressed in several structures, including adult central nervous system; adult digestive system; adult muscle system; adult mushroom body; and adult peripheral nervous system. Orthologous to human CNOT9 (CCR4-NOT transcription complex subunit 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Rcd-1 in Genome Data Viewer
Location:
18D11-18D11; 1-63 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19638767..19640746)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19532800..19534779)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene MAPK Phosphatase 4 Neighboring gene uncharacterized protein Neighboring gene enhancer of yellow 3 Neighboring gene uncharacterized protein Neighboring gene Sec61 gamma subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rapid Cis-Trans Coevolution Driven by a Novel Gene Retroposed from a Eukaryotic Conserved CCR4-NOT Component in Drosophila. Krinsky BH, et al. Genes (Basel), 2021 Dec 26. PMID 35052398, Free PMC Article
  2. Evolution of H3K27me3-marked chromatin is linked to gene expression evolution and to patterns of gene duplication and diversification. Arthur RK, et al. Genome Res, 2014 Jul. PMID 24985914, Free PMC Article
  3. Reshaping of global gene expression networks and sex-biased gene expression by integration of a young gene. Chen S, et al. EMBO J, 2012 Jun 13. PMID 22543869, Free PMC Article
  4. Rapid Gene Evolution in an Ancient Post-transcriptional and Translational Regulatory System Compensates for Meiotic X Chromosomal Inactivation. Xia S, et al. Mol Biol Evol, 2022 Jan 7. PMID 34626117, Free PMC Article
  5. Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets. Sgromo A, et al. RNA, 2018 Mar. PMID 29255063, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bam regulates the expression of its mRNA targets by recruiting the CCR4-NOT complex through interaction with CAF40.
    Title: Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of CCR4-NOT complex IEA
Inferred from Electronic Annotation
more info
  
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
required for cell differentiation 1
Names
CG14213-PA
CG14213-PB
CG14213-PC
Rcd-1-PA
Rcd-1-PB
Rcd-1-PC
required for cell differentiation 1 ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19638767..19640746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272793.2 → NP_001259722.1  required for cell differentiation 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259722.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF85
    Conserved Domains (1) summary
    pfam04078
    Location:37 → 285
    Rcd1; Cell differentiation family, Rcd1-like

  2. NM_167675.2 → NP_728284.1  required for cell differentiation 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728284.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JVP2
    Related
    FBpp0074513
    Conserved Domains (1) summary
    pfam04078
    Location:40 → 288
    Rcd1; Cell differentiation family, Rcd1-like

  3. NM_134491.4 → NP_608335.1  required for cell differentiation 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608335.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JVP2
    Related
    FBpp0074512
    Conserved Domains (1) summary
    pfam04078
    Location:40 → 288
    Rcd1; Cell differentiation family, Rcd1-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PF85 M9PF85
Q7JVP2 Q7JVP2

Gene LinkOut

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