car carnation [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: carprovided by FlyBase
Official Full Name: carnationprovided by FlyBase
Primary source: FLYBASE:FBgn0000257
Locus tag: Dmel_CG12230
See related: AllianceGenome:FB:FBgn0000257
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Car; carn; CG12230; Dm-Vps33; Dmel\CG12230; l(1)G0447; Vps33; Vps33/carnation; vps33a; Vps33a; Vps33A; VPS33a; Vps33p
Summary: Enables syntaxin binding activity. Involved in several processes, including compound eye pigmentation; lysosomal transport; and vesicle organization. Located in lysosome. Part of CORVET complex and HOPS complex. Is expressed in several structures, including adult head; circulatory system primordium; embryonic/larval hemocyte; embryonic/larval midgut primordium; and somatic trunk mesoderm derivative. Orthologous to human VPS33A (VPS33A core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 18D1-18D1; 1-63 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19566019..19569401)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19460052..19463434)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dVps33B predominantly binds the early endosomal Avl and Car to dSyntaxin16
Title: The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables SNARE binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to syntaxin binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch receptor processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye pigmentation	TAS Traceable Author Statement more info	PubMed
involved_in crinophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in endosomal vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome to lysosome transport	TAS Traceable Author Statement more info	PubMed
involved_in eye pigment granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular transport	TAS Traceable Author Statement more info	PubMed
involved_in ommochrome biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to lysosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of SNARE complex assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of CORVET complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CORVET complex	IDA Inferred from Direct Assay more info	PubMed
part_of CORVET complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of HOPS complex	IDA Inferred from Direct Assay more info	PubMed
part_of HOPS complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of HOPS complex	IPI Inferred from Physical Interaction more info	PubMed
part_of HOPS complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed