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ND-18 NADH dehydrogenase (ubiquinone) 18 kDa subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32936, updated on 9-Dec-2024

Summary

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Official Symbol
ND-18provided by FlyBase
Official Full Name
NADH dehydrogenase (ubiquinone) 18 kDa subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0031021
Locus tag
Dmel_CG12203
See related
AllianceGenome:FB:FBgn0031021
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12203; Dmel\CG12203; dNDUFS4; IP11020p; NDUFS4; NUYM; Q9VWI0
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; embryonic/larval midgut primordium; and gut section. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Leigh disease and nuclear type mitochondrial complex I deficiency 1. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ND-18 in Genome Data Viewer
Location:
18C7-18C7; 1-62 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19492421..19493337)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19386454..19387370)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43260 Neighboring gene pacman Neighboring gene antisense RNA:CR44340 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene kish Neighboring gene 6-phosphofructo-2-kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Feeding difficulties, a key feature of the Drosophila NDUFS4 mitochondrial disease model. Foriel S, et al. Dis Model Mech, 2018 Mar 27. PMID 29590638, Free PMC Article
  2. Structural rather than catalytic role for mitochondrial respiratory chain supercomplexes. Brischigliaro M, et al. Elife, 2023 Oct 12. PMID 37823874, Free PMC Article
  3. A Drosophila Mitochondrial Complex I Deficiency Phenotype Array. Foriel S, et al. Front Genet, 2019. PMID 30972103, Free PMC Article
  4. Measurement of mitochondrial respiratory chain enzymatic activities in Drosophila melanogaster samples. Brischigliaro M, et al. STAR Protoc, 2022 Jun 17. PMID 35479112, Free PMC Article
  5. Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Liu L, et al. Cell, 2015 Jan 15. PMID 25594180, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in electron transport chain IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IC
Inferred by Curator
more info
 PubMed 
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NADH dehydrogenase (ubiquinone) 18 kDa subunit
Names
CG12203-PA
FBpp0074481
NADH ubiquinone oxidoreductase 18 kDa
NADH-ubiquinone oxidoreductase 18 kDa subunit
NADH:ubiquinone oxidoreductase 18 kDa subunit
ND-18-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19492421..19493337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133157.4 → NP_573385.1  NADH dehydrogenase (ubiquinone) 18 kDa subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573385.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1EC13, Q8SZL0, Q9VWI0
    Related
    FBpp0074481
    Conserved Domains (1) summary
    pfam04800
    Location:83 → 178
    ETC_C1_NDUFA4; ETC complex I subunit conserved region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWI0.2 Q9VWI0

Gene LinkOut

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