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Dennd1b DENN domain containing 1B [ Mus musculus (house mouse) ]

Gene ID: 329260, updated on 27-Nov-2024

Summary

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Official Symbol
Dennd1bprovided by MGI
Official Full Name
DENN domain containing 1Bprovided by MGI
Primary source
MGI:MGI:2447812
See related
Ensembl:ENSMUSG00000056268 AllianceGenome:MGI:2447812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4632404N19Rik; 4930467M19Rik; 6820401H01Rik; F730008N07Rik
Summary
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endocytic recycling; positive regulation of GTPase activity; and positive regulation of immune response. Predicted to be located in clathrin-coated vesicle. Predicted to be active in cytosol and nuclear speck. Orthologous to human DENND1B (DENN domain containing 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 2.2), thymus adult (RPKM 1.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dennd1b in Genome Data Viewer
Location:
1 E4; 1 60.84 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (138891447..139103781)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (138963709..139176043)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310009B15 gene Neighboring gene STARR-positive B cell enhancer mm9_chr1:140753241-140753541 Neighboring gene STARR-seq mESC enhancer starr_02468 Neighboring gene RIKEN cDNA 1700019P21 gene Neighboring gene STARR-seq mESC enhancer starr_02470 Neighboring gene STARR-positive B cell enhancer ABC_E4352 Neighboring gene RIKEN cDNA 4930596I21 gene Neighboring gene STARR-positive B cell enhancer mm9_chr1:140872594-140872895 Neighboring gene glutathione S-transferase, mu 5 pseudogene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:140958665-140958966 Neighboring gene STARR-seq mESC enhancer starr_02473 Neighboring gene STARR-positive B cell enhancer mm9_chr1:141053030-141053331 Neighboring gene predicted gene 16304 Neighboring gene predicted gene, 57793 Neighboring gene STARR-seq mESC enhancer starr_02474 Neighboring gene predicted gene, 41960 Neighboring gene crumbs family member 1, photoreceptor morphogenesis associated Neighboring gene STARR-seq mESC enhancer starr_02475 Neighboring gene STARR-positive B cell enhancer ABC_E3309 Neighboring gene RIKEN cDNA 4933436E23 gene Neighboring gene STARR-seq mESC enhancer starr_02477 Neighboring gene predicted gene, 34816

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel DENND1B-localized structure found at the basal side of adherent cells. Park EW, et al. Histochem Cell Biol, 2021 Jan. PMID 33135087
  2. Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease. Yang CW, et al. Cell, 2016 Jan 14. PMID 26774822
  3. Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition. Akagi K, et al. Genome Res, 2008 Jun. PMID 18381897, Free PMC Article
  4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC51484

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of T-helper 2 cell cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 1B
Names
ASL1/9AS1-1 fusion
DENN/MADD domain containing 1B
connecdenn 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166501.1 → NP_001159973.1  DENN domain-containing protein 1B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC117623, AC138741
    Consensus CDS
    CCDS48384.1
    UniProtKB/Swiss-Prot
    B2RUR7, E9Q246, Q3U1T9, Q8CG96, Q9D5B9
    Related
    ENSMUSP00000127580.2, ENSMUST00000168527.8
    Conserved Domains (3) summary
    smart00801
    Location:303 → 368
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:92 → 271
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 89
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  2. NM_181347.3 → NP_851992.1  DENN domain-containing protein 1B isoform 2

    See identical proteins and their annotated locations for NP_851992.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC138741, AK155727
    Consensus CDS
    CCDS35728.1
    UniProtKB/Swiss-Prot
    Q3U1T9
    Related
    ENSMUSP00000092082.4, ENSMUST00000094505.6
    Conserved Domains (2) summary
    smart00801
    Location:228 → 293
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:17 → 196
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    138891447..139103781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529716.5 → XP_006529779.1  DENN domain-containing protein 1B isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:323 → 388
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:92 → 291
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 89
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  2. XM_036165904.1 → XP_036021797.1  DENN domain-containing protein 1B isoform X5

    Conserved Domains (3) summary
    smart00801
    Location:240 → 305
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:92 → 227
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 89
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  3. XM_036165909.1 → XP_036021802.1  DENN domain-containing protein 1B isoform X7

    Conserved Domains (3) summary
    smart00801
    Location:220 → 285
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:92 → 207
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 89
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  4. XM_036165910.1 → XP_036021803.1  DENN domain-containing protein 1B isoform X8

    Conserved Domains (3) summary
    smart00801
    Location:323 → 388
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:92 → 291
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 89
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  5. XM_036165911.1 → XP_036021804.1  DENN domain-containing protein 1B isoform X9

    Conserved Domains (3) summary
    smart00801
    Location:303 → 368
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:92 → 271
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 89
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  6. XM_036165912.1 → XP_036021805.1  DENN domain-containing protein 1B isoform X10

    UniProtKB/TrEMBL
    C6EQJ8
    Conserved Domains (1) summary
    pfam03455
    Location:1 → 38
    dDENN; dDENN domain

  7. XM_006529719.4 → XP_006529782.1  DENN domain-containing protein 1B isoform X6

    Conserved Domains (2) summary
    smart00801
    Location:225 → 290
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:21 → 193
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

  8. XM_006529718.4 → XP_006529781.1  DENN domain-containing protein 1B isoform X4

    Conserved Domains (2) summary
    smart00801
    Location:245 → 310
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:21 → 213
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

  9. XM_006529717.4 → XP_006529780.1  DENN domain-containing protein 1B isoform X2

    Conserved Domains (3) summary
    smart00801
    Location:287 → 352
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:56 → 255
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 53
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  10. XM_030255029.2 → XP_030110889.1  DENN domain-containing protein 1B isoform X3

    Conserved Domains (3) summary
    smart00801
    Location:267 → 332
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:56 → 235
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 53
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  11. XM_036165915.1 → XP_036021808.1  DENN domain-containing protein 1B isoform X10

    UniProtKB/TrEMBL
    C6EQJ8
    Conserved Domains (1) summary
    pfam03455
    Location:1 → 38
    dDENN; dDENN domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183217.2: Suppressed sequence

    Description
    NM_183217.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U1T9.3 GenPept UniProtKB/Swiss-Prot:Q3U1T9

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