Clpsl2 colipase-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clpsl2provided by MGI
Official Full Name: colipase-like 2provided by MGI
Primary source: MGI:MGI:2685595
See related: Ensembl:ENSMUSG00000024224 AllianceGenome:MGI:2685595
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm749
Summary: Predicted to enable enzyme activator activity. Predicted to be involved in response to food. Predicted to be located in extracellular region. Orthologous to human CLPSL2 (colipase like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward genital fat pad adult (RPKM 515.4) See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 14.75 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (28768461..28771592)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (28549487..28552618)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study identified a novel and conserved molecule, Clpsl2, was specifically expressed in epididymis and involved in the regulation of spermatozoa motility, acrosomal integrity, and male fertility.
Title: An epididymis-specific secretory protein Clpsl2 critically regulates sperm motility, acrosomal integrity, and male fertility.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in digestion	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to food	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: colipase-like protein 2

Names: colipase-like protein C6orf126 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034871.2 → NP_001030043.1 colipase-like protein 2 precursor

See identical proteins and their annotated locations for NP_001030043.1

Status: PROVISIONAL

Source sequence(s)

AK136682

Consensus CDS

CCDS50047.1

UniProtKB/Swiss-Prot

Q3UW21

Related

ENSMUSP00000025061.5, ENSMUST00000025061.6

Conserved Domains (1) summary

cl24053
Location:27 → 93

COLIPASE; Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation