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CG6659 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32854, updated on 4-Jan-2025

Summary

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Official Symbol
CG6659provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030946
Locus tag
Dmel_CG6659
See related
AllianceGenome:FB:FBgn0030946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6659
Summary
Predicted to enable mannosyltransferase activity. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in spermatogenic failure 9. Orthologous to several human genes including DPY19L1 (dpy-19 like C-mannosyltransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG6659 in Genome Data Viewer
Location:
17C7-17D1; 1-60 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18653392..18657286, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18547425..18551319, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nucleoporin 35kDa Neighboring gene Houki Neighboring gene Inhibitor of growth family, member 3 Neighboring gene fused Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45514

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. Dalton HM, et al. PLoS Genet, 2022 Sep. PMID 36166480, Free PMC Article
  2. An anti-inflammatory transcriptional cascade conserved from flies to humans. Pavlidaki A, et al. Cell Rep, 2022 Oct 18. PMID 36261018
  3. A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins. Guichard A, et al. Cell Rep, 2023 Aug 29. PMID 37480566, Free PMC Article
  4. Expression-Based Cell Lineage Analysis in Drosophila Through a Course-Based Research Experience for Early Undergraduates. Olson JM, et al. G3 (Bethesda), 2019 Nov 5. PMID 31690598, Free PMC Article
  5. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6659-PA
CG6659-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18653392..18657286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133089.2 → NP_573317.1  uncharacterized protein Dmel_CG6659, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573317.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7KUV6, Q9VWR8, Q9VWR9
    Related
    FBpp0074383, FBtr0074612
    Conserved Domains (2) summary
    pfam06614
    Location:521 → 599
    Neuromodulin; Neuromodulin
    pfam10034
    Location:18 → 852
    Dpy19; Q-cell neuroblast polarization

  2. NM_167627.1 → NP_728189.1  uncharacterized protein Dmel_CG6659, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728189.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VWR8
    Related
    FBpp0074384, FBtr0074613
    Conserved Domains (1) summary
    pfam10034
    Location:1 → 737
    Dpy19; Q-cell neuroblast polarization
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWR8.1 Q9VWR8

Gene LinkOut

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