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Mvb12 Multivesicular body subunit 12 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32791, updated on 4-Jan-2025

Summary

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Official Symbol
Mvb12provided by FlyBase
Official Full Name
Multivesicular body subunit 12provided by FlyBase
Primary source
FLYBASE:FBgn0030894
Locus tag
Dmel_CG7192
See related
AllianceGenome:FB:FBgn0030894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7192; Dmel\CG7192
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including endosome to lysosome transport via multivesicular body sorting pathway; receptor catabolic process; and regulation of epidermal growth factor receptor signaling pathway. Predicted to be part of ESCRT I complex. Predicted to be active in cytosol. Orthologous to several human genes including MVB12A (multivesicular body subunit 12A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Mvb12 in Genome Data Viewer
Location:
16F6-16F6; 1-59 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18097558..18101314, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17991591..17995347, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene scully Neighboring gene Rho GTPase activating protein at 16F Neighboring gene TBP-associated factor 8 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia. Wang L, et al. Sci Adv, 2022 Jul 15. PMID 35857503, Free PMC Article
  2. Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles. Thomas RE, et al. PLoS Genet, 2018 Sep. PMID 30256786, Free PMC Article
  3. Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. Vaccari T, et al. J Cell Sci, 2009 Jul 15. PMID 19571114, Free PMC Article
  4. Developmental and cellular functions of the ESCRT machinery in pluricellular organisms. Michelet X, et al. Biol Cell, 2010 Jan 13. PMID 20059450
  5. The vacuolar protein sorting genes in insects: A comparative genome view. Li Z, et al. Insect Biochem Mol Biol, 2015 Jul. PMID 25486452

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endosome to lysosome transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in viral budding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in virus maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex IEA
Inferred from Electronic Annotation
more info
  
part_of ESCRT I complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
multivesicular body subunit 12
Names
CG7192-PA
CG7192-PB
CG7192-PD
Mvb12-PA
Mvb12-PB
Mvb12-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18097558..18101314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133040.3 → NP_573268.1  multivesicular body subunit 12, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573268.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWY7
    Related
    FBpp0074301
    Conserved Domains (1) summary
    pfam10240
    Location:56 → 334
    DUF2464; Protein of unknown function (DUF2464)

  2. NM_001258802.1 → NP_001245731.1  multivesicular body subunit 12, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245731.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWY7
    Conserved Domains (1) summary
    pfam10240
    Location:56 → 334
    DUF2464; Protein of unknown function (DUF2464)

  3. NM_167602.2 → NP_728135.1  multivesicular body subunit 12, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728135.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWY7
    Related
    FBpp0074302
    Conserved Domains (1) summary
    pfam10240
    Location:56 → 334
    DUF2464; Protein of unknown function (DUF2464)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWY7 Q9VWY7

Gene LinkOut

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