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CG6769 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32770, updated on 9-Dec-2024

Summary

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Official Symbol
CG6769provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030878
Locus tag
Dmel_CG6769
See related
AllianceGenome:FB:FBgn0030878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6769; Vms1
Summary
Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Predicted to be part of preribosome, large subunit precursor. Is expressed in several structures, including embryonic/larval crystal cell; embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle system; and mesoderm. Used to study azoospermia. Orthologous to human ZNF622 (zinc finger protein 622). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG6769 in Genome Data Viewer
Location:
16E2-16E2; 1-59 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17861002..17862775)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17755035..17756808)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43981 Neighboring gene Sulfiredoxin Neighboring gene Actin-related protein 8 Neighboring gene minibrain Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis. Geng J, et al. Nat Commun, 2024 Feb 22. PMID 38388640, Free PMC Article
  2. Relating past and present diet to phenotypic and transcriptomic variation in the fruit fly. May CM, et al. BMC Genomics, 2017 Aug 22. PMID 28830340, Free PMC Article
  3. Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease. Rimal S, et al. Acta Neuropathol Commun, 2021 Oct 18. PMID 34663454, Free PMC Article
  4. Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila. Yu J, et al. Hum Mol Genet, 2015 Mar 1. PMID 25361961
  5. Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD. Li S, et al. Proc Natl Acad Sci U S A, 2020 Oct 6. PMID 32958650, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6769-PA
CG6769-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17861002..17862775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272734.1 → NP_001259663.1  uncharacterized protein Dmel_CG6769, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259663.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX08
    Conserved Domains (3) summary
    sd00020
    Location:6 → 28
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:70 → 94
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam12756
    Location:191 → 290
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)

  2. NM_133024.4 → NP_573252.1  uncharacterized protein Dmel_CG6769, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573252.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX08
    Related
    FBpp0074267
    Conserved Domains (3) summary
    sd00020
    Location:6 → 28
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:70 → 94
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam12756
    Location:191 → 290
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VX08 Q9VX08

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