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CG15814 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32765, updated on 9-Dec-2024

Summary

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Official Symbol
CG15814provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030873
Locus tag
Dmel_CG15814
See related
AllianceGenome:FB:FBgn0030873
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG15814
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in ERAD pathway. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; gland; and salivary gland body primordium. Orthologous to human RNF121 (ring finger protein 121) and RNF175 (ring finger protein 175). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG15814 in Genome Data Viewer
Location:
16E1-16E1; 1-59 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17848110..17850342, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17742143..17744375, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44691 Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 9 Neighboring gene uncharacterized protein Neighboring gene Uncoupling protein 4A Neighboring gene Spt7 Neighboring gene uncharacterized protein Neighboring gene Multicopper oxidase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of Drosophila. Landry CR, et al. Genetics, 2005 Dec. PMID 16143608, Free PMC Article
  2. Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model. Park JE, et al. Exp Mol Med, 2023 Jul. PMID 37464094, Free PMC Article
  3. X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila. Legube G, et al. Genes Dev, 2006 Apr 1. PMID 16547175, Free PMC Article
  4. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article
  5. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG15814-PA
CG15814-PB
CG15814-PC
CG15814-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17848110..17850342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167577.3 → NP_728098.1  uncharacterized protein Dmel_CG15814, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728098.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SS4, Q9VX13
    Related
    FBpp0074242
    Conserved Domains (1) summary
    pfam13639
    Location:218 → 270
    zf-RING_2; Ring finger domain

  2. NM_167578.3 → NP_728099.1  uncharacterized protein Dmel_CG15814, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728099.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SS4, Q9VX13
    Related
    FBpp0074244
    Conserved Domains (1) summary
    pfam13639
    Location:218 → 270
    zf-RING_2; Ring finger domain

  3. NM_133019.4 → NP_573247.2  uncharacterized protein Dmel_CG15814, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573247.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SS4, Q9VX13
    Related
    FBpp0074243
    Conserved Domains (1) summary
    pfam13639
    Location:218 → 270
    zf-RING_2; Ring finger domain

  4. NM_167579.2 → NP_728100.1  uncharacterized protein Dmel_CG15814, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728100.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQZ5, Q95SS4
    Related
    FBpp0074245
    Conserved Domains (1) summary
    pfam13639
    Location:198 → 250
    zf-RING_2; Ring finger domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQZ5 Q8IQZ5
Q95SS4 Q95SS4
Q9VX13 Q9VX13

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