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gnsb glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b [ Danio rerio (zebrafish) ]

Gene ID: 327635, updated on 9-Dec-2024

Summary

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Official Symbol
gnsbprovided by ZNC
Official Full Name
glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5846
See related
Ensembl:ENSDARG00000098296 AllianceGenome:ZFIN:ZDB-GENE-030131-5846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gns; zgc:55370; wu:fi20h10
Summary
Predicted to enable N-acetylglucosamine-6-sulfatase activity and glycosaminoglycan binding activity. Predicted to be involved in glycosaminoglycan metabolic process. Predicted to be located in lysosome. Is expressed in pronephric duct and yolk syncytial layer. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See gnsb in Genome Data Viewer
Location:
chromosome: 10
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (45031398..45047818)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (45184786..45200630)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene ventrally expressed dharma/bozozok antagonist Neighboring gene polymerase (DNA directed), mu Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene NudC domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylglucosamine-6-sulfatase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glycosaminoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycosaminoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b
NP_956135.2
XP_021334786.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199841.2 → NP_956135.2  glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b precursor

    Status: VALIDATED

    Source sequence(s)
    CU896586
    UniProtKB/TrEMBL
    A0A0R4IMG2, A0A8M1PFZ3
    Related
    ENSDARP00000135019.1, ENSDART00000160536.2
    Conserved Domains (2) summary
    COG3119
    Location:34 → 496
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16147
    Location:34 → 480
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    45031398..45047818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479111.2 → XP_021334786.1  glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b isoform X1

    UniProtKB/TrEMBL
    A0A8M9QGE4
    Conserved Domains (1) summary
    cd16147
    Location:1 → 428
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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