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lpcat4 lysophosphatidylcholine acyltransferase 4 [ Danio rerio (zebrafish) ]

Gene ID: 327566, updated on 4-Jan-2025

Summary

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Official Symbol
lpcat4provided by ZNC
Official Full Name
lysophosphatidylcholine acyltransferase 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5777
See related
Ensembl:ENSDARG00000035028 AllianceGenome:ZFIN:ZDB-GENE-030131-5777
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:77292; wu:fb10c07; wu:fi17g10
Summary
Predicted to enable lysophosphatidic acid acyltransferase activity. Predicted to be involved in phospholipid metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in EVL. Orthologous to human LPCAT4 (lysophosphatidylcholine acyltransferase 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See lpcat4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (1473939..1495964)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (1337859..1359884)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene cylindromatosis (turban tumor syndrome) 3 Neighboring gene uncharacterized LOC137496114 Neighboring gene ER membrane protein complex subunit 4 Neighboring gene uncharacterized LOC137496113 Neighboring gene NOP10 ribonucleoprotein homolog (yeast)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of Dietary Supplementation with Aurantiochytrium sp. on Zebrafish Growth as Determined by Transcriptomics. Yang H, et al. Animals (Basel), 2022 Oct 16. PMID 36290180, Free PMC Article
  2. UPLC-TOF-MS/MS metabolomics analysis of zebrafish metabolism by spirotetramat. Zhang J, et al. Environ Pollut, 2020 Nov. PMID 32798906
  3. n-3 PUFA reduction caused by fabp2 deletion interferes with triacylglycerol metabolism and cholesterolhomeostasis in fish. Zhao Y, et al. Appl Microbiol Biotechnol, 2020 Mar. PMID 31950220
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-acylglycerophosphocholine O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables lysophosphatidic acid acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysophospholipid acyltransferase LPCAT4
NP_991122.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205559.2 → NP_991122.2  lysophospholipid acyltransferase LPCAT4

    Status: VALIDATED

    Source sequence(s)
    CU905505, EH483770, EH541464, FP139120
    UniProtKB/TrEMBL
    A0A8M1PGC0, F1QD35
    Related
    ENSDARP00000050686.5, ENSDART00000050687.6
    Conserved Domains (2) summary
    cd07991
    Location:85 → 291
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG0204
    Location:42 → 305
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    1473939..1495964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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