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f5 coagulation factor V [ Danio rerio (zebrafish) ]

Gene ID: 327320, updated on 9-Dec-2024

Summary

Official Symbol
f5provided by ZNC
Official Full Name
coagulation factor Vprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5531
See related
Ensembl:ENSDARG00000055705 AllianceGenome:ZFIN:ZDB-GENE-030131-5531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fd21h06; si:bz20i5.3
Summary
Predicted to enable copper ion binding activity and oxidoreductase activity. Acts upstream of or within hemostasis and response to bacterium. Predicted to be located in extracellular region. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); end stage renal disease; factor V deficiency; liver disease (multiple); and non-arteritic anterior ischemic optic neuropathy. Orthologous to human F5 (coagulation factor V). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

Location:
chromosome: 9
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (34127005..34147996)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (34317820..34338811)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496428 Neighboring gene coiled-coil domain containing 80 Neighboring gene solute carrier family 35 member A5 Neighboring gene G protein-coupled receptor 161b Neighboring gene ddb1 and cul4 associated factor 6

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
coagulation factor V
Names
coagulation factor V (proaccelerin, labile factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328531.1NP_001315460.1  coagulation factor V precursor

    Status: VALIDATED

    Source sequence(s)
    AL590146
    UniProtKB/TrEMBL
    A0A0R4ICY4, A0A8M1PAE6, B7ZVT7
    Related
    ENSDARP00000132592.2, ENSDART00000167384.2
    Conserved Domains (10) summary
    PHA03151
    Location:11241228
    PHA03151; hypothetical protein; Provisional
    smart00231
    Location:19282084
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    COG5099
    Location:8231247
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd00057
    Location:19322083
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd04226
    Location:28187
    CuRO_1_FV_like; The first cupredoxin domain of coagulation factor VIII and similar proteins
    cd14450
    Location:345522
    CuRO_3_FV_like; The third cupredoxin domain of coagulation factor V and similar proteins
    cd14453
    Location:199323
    CuRO_2_FV_like; The second cupredoxin domain of coagulation factor V and similar proteins
    cd14454
    Location:535678
    CuRO_4_FV_like; The fourth cupredoxin domain of coagulation factor V and similar proteins
    cd14455
    Location:16291770
    CuRO_6_FV_like; The sixth cupredoxin domain of coagulation factor V and similar proteins
    cl19115
    Location:14471620
    Cupredoxin; Cupredoxin superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    34127005..34147996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007208.2: Suppressed sequence

    Description
    NM_001007208.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.