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Ankle2 Ankle2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32732, updated on 4-Jan-2025

Summary

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Official Symbol
Ankle2provided by FlyBase
Official Full Name
Ankle2provided by FlyBase
Primary source
FLYBASE:FBgn0028343
Locus tag
Dmel_CG8465
See related
AllianceGenome:FB:FBgn0028343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Ankle-2; anon-WO03040301.175; anon-WO03040301.177; anon-WO03040301.179; CG8465; dAnkle2; Dmel\CG8465; l(1)G0222; l(1)G0316
Summary
Predicted to enable protein phosphatase 2A binding activity. Predicted to be involved in mitotic nuclear membrane reassembly. Located in endoplasmic reticulum and nuclear envelope. Is expressed in adult brain cell body rind; central brain primordium; embryonic brain; and organism. Used to study microcephaly and primary autosomal recessive microcephaly 16. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ankle2 in Genome Data Viewer
Location:
16B5-16B6; 1-57 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17571854..17579229, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17465887..17473262, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44692 Neighboring gene antisense RNA:CR44124 Neighboring gene pickpocket 23 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene X11L

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis. Shah PS, et al. Cell, 2018 Dec 13. PMID 30550790, Free PMC Article
  2. ANKLE2-related microcephaly: A variable microcephaly syndrome resembling Zika infection. Thomas AX, et al. Ann Clin Transl Neurol, 2022 Aug. PMID 35871307, Free PMC Article
  3. Nuclear reassembly defects after mitosis trigger apoptotic and p53-dependent safeguard mechanisms in Drosophila. Li J, et al. PLoS Biol, 2024 Aug. PMID 39186808, Free PMC Article
  4. A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Yamamoto S, et al. Cell, 2014 Sep 25. PMID 25259927, Free PMC Article
  5. Comprehensive review on the molecular genetics of autosomal recessive primary microcephaly (MCPH). Naveed M, et al. Genet Res (Camb), 2018 Aug 8. PMID 30086807, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein phosphatase 2A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitotic nuclear membrane reassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ankle2
Names
ANKLE2 ortholog
Ankle2-PD
Ankle2-PE
Ankle2-PF
Ankle2-PG
CG8465-PD
CG8465-PE
CG8465-PF
CG8465-PG
ankyrin repeat and LEM domain containing 2
l(1)G0222
lethal (1) G0222

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17571854..17579229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298446.1 → NP_001285375.1  Ankle2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285375.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JCC5
    Conserved Domains (3) summary
    cd00204
    Location:243 → 375
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:282 → 361
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:280 → 335
    ANK; ANK repeat [structural motif]

  2. NM_132993.3 → NP_573221.2  Ankle2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573221.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHR1, Q8MQX9, Q9VX44, X2JCC5
    Conserved Domains (2) summary
    sd00045
    Location:280 → 335
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:281 → 361
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_167569.2 → NP_728082.2  Ankle2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728082.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHR1, Q8MQX9, Q9VX44, X2JCC5
    Conserved Domains (2) summary
    sd00045
    Location:280 → 335
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:281 → 361
    Ank_2; Ankyrin repeats (3 copies)

  4. NM_167570.2 → NP_728083.2  Ankle2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728083.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX44
    Conserved Domains (3) summary
    cd00204
    Location:179 → 311
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:218 → 297
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:216 → 271
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MQX9.1 Q8MQX9

Gene LinkOut

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