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ppk23 pickpocket 23 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32731, updated on 4-Jan-2025

Summary

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Official Symbol
ppk23provided by FlyBase
Official Full Name
pickpocket 23provided by FlyBase
Primary source
FLYBASE:FBgn0030844
Locus tag
Dmel_CG8527
See related
AllianceGenome:FB:FBgn0030844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8527; Dmel\CG8527; ppk-23; PPK-23; Ppk23; PPK23
Summary
Predicted to enable ligand-gated sodium channel activity. Involved in detection of pheromone and male courtship behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult prothoracic segment; appendage; ganglia; gustatory receptor neurons; and labellum. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See ppk23 in Genome Data Viewer
Location:
16B4-16B4; 1-57 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17566552..17569228, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17460585..17463261, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44692 Neighboring gene antisense RNA:CR44124 Neighboring gene Ankle2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Measuring Physiological Responses of Drosophila Sensory Neurons to Lipid Pheromones Using Live Calcium Imaging. Shankar S, et al. J Vis Exp, 2016 Apr 29. PMID 27168110, Free PMC Article
  2. Evolution of a central neural circuit underlies Drosophila mate preferences. Seeholzer LF, et al. Nature, 2018 Jul. PMID 29995860, Free PMC Article
  3. The Drosophila female aphrodisiac pheromone activates ppk23(+) sensory neurons to elicit male courtship behavior. Toda H, et al. Cell Rep, 2012 Jun 28. PMID 22813735
  4. Larval microbiota primes the Drosophila adult gustatory response. Montanari M, et al. Nat Commun, 2024 Feb 13. PMID 38351056, Free PMC Article
  5. Regulation of sleep homeostasis by sexual arousal. Beckwith EJ, et al. Elife, 2017 Sep 12. PMID 28893376, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data identify the ppk23(+) sensory neurons as the primary targets for female sex pheromones in Drosophila.
    Title: The Drosophila female aphrodisiac pheromone activates ppk23(+) sensory neurons to elicit male courtship behavior.
  2. these data indicate that ppk23 and the cells expressing it play an important role in the peripheral sensory system that determines sexual behavior in Drosophila.
    Title: ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligand-gated sodium channel activity IC
Inferred by Curator
more info
 PubMed 
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in detection of pheromone IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_positive_effect male courtship behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in male courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pickpocket 23
Names
CG8527-PA
CG8527-PB
CG8527-PC
CG8527-PD
ppk23-PA
ppk23-PB
ppk23-PC
ppk23-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17566552..17569228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272717.1 → NP_001259646.1  pickpocket 23, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259646.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F8QU26, M9PHF4
    Conserved Domains (1) summary
    pfam00858
    Location:34 → 451
    ASC; Amiloride-sensitive sodium channel

  2. NM_001103541.3 → NP_001097011.1  pickpocket 23, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097011.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JV41, F8QU26
    Conserved Domains (1) summary
    pfam00858
    Location:34 → 476
    ASC; Amiloride-sensitive sodium channel

  3. NM_132992.3 → NP_573220.2  pickpocket 23, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573220.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86LG2, Q9VX46
    Conserved Domains (1) summary
    pfam00858
    Location:34 → 451
    ASC; Amiloride-sensitive sodium channel

  4. NM_001014749.2 → NP_001014749.1  pickpocket 23, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014749.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86LG2, Q86LG3
    Conserved Domains (1) summary
    pfam00858
    Location:34 → 476
    ASC; Amiloride-sensitive sodium channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JV41 A8JV41
M9PHF4 M9PHF4
Q86LG2 Q86LG2
Q86LG3 Q86LG3
Q9VX46 Q9VX46

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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