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sec22bb SEC22 homolog B, vesicle trafficking protein b [ Danio rerio (zebrafish) ]

Gene ID: 327277, updated on 4-Jan-2025

Summary

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Official Symbol
sec22bbprovided by ZNC
Official Full Name
SEC22 homolog B, vesicle trafficking protein bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5488
See related
Ensembl:ENSDARG00000100435 AllianceGenome:ZFIN:ZDB-GENE-030131-5488
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sec22l1b; wu:fd20b06
Summary
Predicted to enable SNAP receptor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; and vesicle fusion with Golgi apparatus. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment membrane; and melanosome. Predicted to be part of SNARE complex. Predicted to be active in ER to Golgi transport vesicle membrane; Golgi membrane; and endoplasmic reticulum membrane. Orthologous to human SEC22B (SEC22 homolog B, vesicle trafficking protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See sec22bb in Genome Data Viewer
Location:
chromosome: 8
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (19504011..19512270)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (19471926..19480185)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene ER degradation enhancer, mannosidase alpha-like 3 Neighboring gene si:ch73-281k2.5 Neighboring gene N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) Neighboring gene notch receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish retinoid-related orphan receptor (ror) gene family. Flores MV, et al. Gene Expr Patterns, 2007 Apr. PMID 17374568
  2. The BH3-only SNARE BNip1 mediates photoreceptor apoptosis in response to vesicular fusion defects. Nishiwaki Y, et al. Dev Cell, 2013 May 28. PMID 23725763
  3. Syntaxin 18 Defects in Human and Zebrafish Unravel Key Roles in Early Cartilage and Bone Development. Guillemyn B, et al. J Bone Miner Res, 2023 Nov. PMID 37718532
  4. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle fusion with Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vesicle-trafficking protein SEC22b-B
Names
SEC22 vesicle trafficking protein homolog B, b
SEC22, vesicle trafficking protein-like 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328526.1 → NP_001315455.1  vesicle-trafficking protein SEC22b-B isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT573380, EH489983, EH493956, EH528230, EH596279
    UniProtKB/TrEMBL
    A0A0R4IQP5, A0A8M1PAE1, A7MCK9
    Related
    ENSDARP00000137821.2, ENSDART00000158859.2
    Conserved Domains (3) summary
    COG5143
    Location:12 → 192
    SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
    cd15866
    Location:136 → 199
    R-SNARE_SEC22; SNARE motif of SEC22
    pfam13774
    Location:41 → 107
    Longin; Regulated-SNARE-like domain

  2. NM_201302.2 → NP_958459.1  vesicle-trafficking protein SEC22b-B isoform 2

    See identical proteins and their annotated locations for NP_958459.1

    Status: VALIDATED

    Source sequence(s)
    CT573380, EH489983, EH493956, EH528230, EH596279
    UniProtKB/Swiss-Prot
    Q7SXP0
    Related
    ENSDARP00000136767.1, ENSDART00000159044.2
    Conserved Domains (3) summary
    COG5143
    Location:12 → 188
    SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
    cd15866
    Location:132 → 195
    R-SNARE_SEC22; SNARE motif of SEC22
    pfam13774
    Location:37 → 103
    Longin; Regulated-SNARE-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    19504011..19512270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SXP0.1 GenPept UniProtKB/Swiss-Prot:Q7SXP0

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