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CG5445 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32722, updated on 9-Dec-2024

Summary

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Official Symbol
CG5445provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030838
Locus tag
Dmel_CG5445
See related
AllianceGenome:FB:FBgn0030838
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5445
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in macroautophagy. Predicted to be active in phagophore assembly site. Is expressed in organism. Orthologous to human ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG5445 in Genome Data Viewer
Location:
15F7-16A1; 1-57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17282496..17305475)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17176529..17199508)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene forked Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fimbrin Neighboring gene BarH2 Neighboring gene long non-coding RNA:CR43491

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-Linked TDP-43 in Drosophila. Uechi H, et al. Mol Cell Biol, 2018 Feb 1. PMID 29109084, Free PMC Article
  2. Amyotrophic Lateral Sclerosis Genes in Drosophila melanogaster. Layalle S, et al. Int J Mol Sci, 2021 Jan 18. PMID 33477509, Free PMC Article
  3. A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila. Nagarkar-Jaiswal S, et al. Elife, 2015 Mar 31. PMID 25824290, Free PMC Article
  4. Expression-Based Cell Lineage Analysis in Drosophila Through a Course-Based Research Experience for Early Undergraduates. Olson JM, et al. G3 (Bethesda), 2019 Nov 5. PMID 31690598, Free PMC Article
  5. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5445-PA
CG5445-PB
CG5445-PD
CG5445-PF
CG5445-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17282496..17305475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298442.1 → NP_001285371.1  uncharacterized protein Dmel_CG5445, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285371.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX56
    Conserved Domains (2) summary
    cd14349
    Location:129 → 170
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cl22423
    Location:197 → 261
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

  2. NM_176748.2 → NP_788921.1  uncharacterized protein Dmel_CG5445, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788921.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX56
    Related
    FBpp0074202
    Conserved Domains (2) summary
    cd14349
    Location:129 → 170
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cl22423
    Location:197 → 261
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

  3. NM_132985.4 → NP_573213.1  uncharacterized protein Dmel_CG5445, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573213.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX56
    Related
    FBpp0074201
    Conserved Domains (2) summary
    cd14349
    Location:129 → 170
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cl22423
    Location:197 → 261
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

  4. NM_167568.3 → NP_728077.1  uncharacterized protein Dmel_CG5445, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728077.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX56
    Related
    FBpp0308824
    Conserved Domains (2) summary
    cd14349
    Location:129 → 170
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cl22423
    Location:197 → 261
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

  5. NM_167567.2 → NP_728076.1  uncharacterized protein Dmel_CG5445, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728076.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX56
    Related
    FBpp0074199
    Conserved Domains (2) summary
    cd14349
    Location:129 → 170
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cl22423
    Location:197 → 261
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VX56 Q9VX56

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