tmem33 transmembrane protein 33 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tmem33provided by ZNC
Official Full Name: transmembrane protein 33provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5425
See related: Ensembl:ENSDARG00000041332 AllianceGenome:ZFIN:ZDB-GENE-030131-5425
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55931; zgc:77670; wu:fd16h10; wu:fi11f08
Summary: Acts upstream of or within regulation of sprouting angiogenesis; regulation of store-operated calcium channel activity; and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in pronephros and trunk vasculature. Orthologous to human TMEM33 (transmembrane protein 33). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (46342989..46352812)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (47369041..47378876)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that TMEM33 interacts with the ion channel polycystin-2 at the endoplasmic reticulum (ER) membrane, enhancing its opening over the whole physiological calcium range in ER liposomes fused to planar bilayers. Results identify a key role for TMEM33 in the regulation of intracellular calcium homeostasis of renal proximal convoluted tubule cells and establish a causal link between TMEM33 and acute kidney injury.
Title: TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells.
Knockdown of transmembrane protein 33 (tmem33) impairs multiple downstream effects of vascular endothelial growth factor (VEGF).
Title: tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum tubular network organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of store-operated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213663.1 → NP_998828.1 transmembrane protein 33

See identical proteins and their annotated locations for NP_998828.1

Status: PROVISIONAL

Source sequence(s)

BC044544

UniProtKB/TrEMBL

A0A2R8Q152, F6P6T9, Q803C2

Related

ENSDARP00000060576.4, ENSDART00000060577.7

Conserved Domains (1) summary

pfam03661
Location:16 → 250

UPF0121; uncharacterized protein family (UPF0121)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

46342989..46352812

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017358989.3 → XP_017214478.1 transmembrane protein 33 isoform X1

UniProtKB/TrEMBL

A0A2R8Q152, F6P6T9, Q803C2

Conserved Domains (1) summary

pfam03661
Location:16 → 250

UPF0121; uncharacterized protein family (UPF0121)