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rac1a Rac family small GTPase 1a [ Danio rerio (zebrafish) ]

Gene ID: 327204, updated on 9-Dec-2024

Summary

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Official Symbol
rac1aprovided by ZNC
Official Full Name
Rac family small GTPase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5415
See related
Ensembl:ENSDARG00000074849 AllianceGenome:ZFIN:ZDB-GENE-030131-5415
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rac1; zgc:55823; zgc:55917; zgc:86934; wu:fd16e02
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within cell migration involved in gastrulation; myoblast fusion; and neutrophil chemotaxis. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and dendritic spine. Is expressed in liver; retina; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 48; colorectal cancer (multiple); lung cancer; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See rac1a in Genome Data Viewer
Location:
chromosome: 12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (10464897..10476337, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (10427054..10438494, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein b (U4/U6.U5) Neighboring gene crystallin, mu Neighboring gene Sad1 and UNC84 domain containing 1a Neighboring gene myoferlin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish. Mikdache A, et al. Cell Mol Life Sci, 2020 Jan. PMID 31161284, Free PMC Article
  2. Bulk Actin Dynamics Drive Phase Segregation in Zebrafish Oocytes. Shamipour S, et al. Cell, 2019 May 30. PMID 31080065
  3. RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes. Reijnders MRF, et al. Am J Hum Genet, 2017 Sep 7. PMID 28886345, Free PMC Article
  4. Ptenb mediates gastrulation cell movements via Cdc42/AKT1 in zebrafish. Yeh CM, et al. PLoS One, 2011 Apr 11. PMID 21494560, Free PMC Article
  5. Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects. Harris JM, et al. Dev Cell, 2020 Jun 8. PMID 32516597, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Early Elmo1 and Rac1 functions are required within Schwann cells to drive radial sorting and myelination.
    Title: Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish.
  2. our data have demonstrated a causal link between excessive Rac1 activity and podocyte injury in a dosage-dependent manner
    Title: Dosage-dependent role of Rac1 in podocyte injury.
  3. Knockdown of fat1 in zebrafish causes pronephric cysts, which is partially rescued by RAC1/CDC42 activators, confirming a role of the two small GTPases in the pathogenesis.
    Title: FAT1 mutations cause a glomerulotubular nephropathy.
  4. ELMO-DOCK1, a bipartite guanine nucleotide exchange factor complex for the small GTPase Rac1, and for the membrane-cytoskeletal linker Ezrin, regulates centriole/basal body migration, docking and spacing.
    Title: The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin.
  5. Our data suggest that Rac contributes to the progression of melanoma and that Tiam1 may activate Rac in nodular presentations.
    Title: Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression.
  6. Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm.
    Title: Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm.
  7. Reducing Rac1 activity in endodermal cells caused them to bypass the random migration phase.
    Title: Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1.
  8. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
    Title: Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC55823

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell migration involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within myoblast fusion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neutrophil migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related C3 botulinum toxin substrate 1
Names
RAS-related C3 botulinum substrate 1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
ras-related C3 botulinum toxin substrate 1a (rho family, small GTP binding protein Rac1)
NP_956065.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199771.1 → NP_956065.1  ras-related C3 botulinum toxin substrate 1

    See identical proteins and their annotated locations for NP_956065.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044538
    UniProtKB/TrEMBL
    F6PDM1, Q49P05, Q7ZSZ9
    Related
    ENSDARP00000096950.4, ENSDART00000106172.5
    Conserved Domains (2) summary
    smart00174
    Location:6 → 179
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01871
    Location:3 → 176
    Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    10464897..10476337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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