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vamp8 vesicle-associated membrane protein 8 (endobrevin) [ Danio rerio (zebrafish) ]

Gene ID: 327007, updated on 4-Jan-2025

Summary

Official Symbol
vamp8provided by ZNC
Official Full Name
vesicle-associated membrane protein 8 (endobrevin)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5215
See related
Ensembl:ENSDARG00000024116 AllianceGenome:ZFIN:ZDB-GENE-030131-5215
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56588; wu:fa18d07
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in SNARE complex assembly and mucus secretion. Predicted to act upstream of or within autophagy; defense response to virus; and vesicle-mediated transport. Predicted to be located in bounding membrane of organelle. Predicted to be part of SNARE complex. Predicted to be active in mucin granule and plasma membrane. Is expressed in otic vesicle; periderm; pharynx; pronephric duct; and sensory system. Orthologous to human VAMP8 (vesicle associated membrane protein 8). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See vamp8 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (28271412..28279364)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (27671259..27679211)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene tachykinin receptor 1a Neighboring gene non-SMC condensin I complex, subunit H Neighboring gene si:dkeyp-86b9.5 Neighboring gene vesicle-associated membrane protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in SNARE complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in mucus secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mucin granule IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in zymogen granule membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
vesicle-associated membrane protein 8
Names
endobrevin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199759.1NP_956053.1  vesicle-associated membrane protein 8

    See identical proteins and their annotated locations for NP_956053.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049333
    UniProtKB/TrEMBL
    A0A2R8QAD4, F6NUW8, Q7ZUC1
    Related
    ENSDARP00000032940.4, ENSDART00000031727.5
    Conserved Domains (2) summary
    cd15868
    Location:2185
    R-SNARE_VAMP8; SNARE motif of VAMP8
    pfam00957
    Location:1985
    Synaptobrevin; Synaptobrevin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    28271412..28279364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394578.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    140680..148844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)