U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

wus wurst [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32683, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
wusprovided by FlyBase
Official Full Name
wurstprovided by FlyBase
Primary source
FLYBASE:FBgn0030805
Locus tag
Dmel_CG9089
See related
AllianceGenome:FB:FBgn0030805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9089; Dmel\CG9089; l(1)G0162
Summary
Involved in endocytosis; extracellular matrix organization; and open tracheal system development. Located in early endosome and plasma membrane. Is expressed in several structures, including adult head; embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; and gut section. Orthologous to human DNAJC22 (DnaJ heat shock protein family (Hsp40) member C22). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See wus in Genome Data Viewer
Location:
15C4-15C4; 1-56 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16938244..16940873, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16832277..16834906, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44754 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rho GTPase activating protein at 15B Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Time-specific regulation of airway clearance by the Drosophila J-domain transmembrane protein Wurst. Stümpges B, et al. FEBS Lett, 2011 Oct 20. PMID 21945316
  2. Expression and localization of clathrin heavy chain in Drosophila melanogaster. Wingen C, et al. Gene Expr Patterns, 2009 Oct. PMID 19577664
  3. A cell surface protein controls endocrine ring gland morphogenesis and steroid production. Pesch YY, et al. Dev Biol, 2019 Jan 1. PMID 30367846
  4. Drosophila Embryos as a Model for Wound-Induced Transcriptional Dynamics: Genetic Strategies to Achieve a Localized Wound Response. Juarez MT. Adv Wound Care (New Rochelle), 2016 Jun 1. PMID 27274436, Free PMC Article
  5. The proteolysis of ZP proteins is essential to control cell membrane structure and integrity of developing tracheal tubes in Drosophila. Drees L, et al. Elife, 2023 Oct 24. PMID 37872795, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in liquid clearance, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube length, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
wurst
Names
CG9089-PA
CG9089-PB
wus-PA
wus-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16938244..16940873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298426.1 → NP_001285355.1  wurst, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285355.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX95
    Conserved Domains (3) summary
    COG0484
    Location:327 → 385
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:331 → 385
    DnaJ; DnaJ domain
    pfam05154
    Location:47 → 97
    TM2; TM2 domain

  2. NM_132952.3 → NP_573180.1  wurst, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573180.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX95
    Related
    FBpp0074192
    Conserved Domains (3) summary
    COG0484
    Location:327 → 385
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:331 → 385
    DnaJ; DnaJ domain
    pfam05154
    Location:47 → 97
    TM2; TM2 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VX95 Q9VX95

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools