U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

arhgap21b Rho GTPase activating protein 21b [ Danio rerio (zebrafish) ]

Gene ID: 326745, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
arhgap21bprovided by ZNC
Official Full Name
Rho GTPase activating protein 21bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4944
See related
Ensembl:ENSDARG00000075673 AllianceGenome:ZFIN:ZDB-GENE-030131-4944
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fe14a09; wu:fe14a09; si:ch211-175p12.1
Summary
Predicted to enable GTPase activator activity and phospholipid binding activity. Predicted to act upstream of or within signal transduction. Orthologous to human ARHGAP21 (Rho GTPase activating protein 21). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See arhgap21b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (12302663..12406641)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (12619528..12723855)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 158b Neighboring gene phosphoribosyl transferase domain containing 1b Neighboring gene dipeptidyl-peptidase 6b Neighboring gene lysine (K)-specific methyltransferase 2Cb

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Rho GTPase activating protein 21; rho GTPase-activating protein 21
Names
spork

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    12302663..12406641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001918933.7 → XP_001918968.3  rho GTPase-activating protein 21 isoform X1

    UniProtKB/TrEMBL
    A0A8M1QQH1, F1QST2
    Related
    ENSDARP00000085731.4, ENSDART00000091298.7
    Conserved Domains (4) summary
    cd00992
    Location:50 → 156
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:1031 → 1227
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:817 → 931
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:817 → 926
    PH; PH domain

  2. XM_009298094.4 → XP_009296369.1  rho GTPase-activating protein 21 isoform X2

    UniProtKB/TrEMBL
    A0A8M3APT5
    Conserved Domains (4) summary
    cd00992
    Location:50 → 156
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:1031 → 1227
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:817 → 931
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:817 → 926
    PH; PH domain

  3. XM_009298105.4 → XP_009296380.1  rho GTPase-activating protein 21 isoform X5

    See identical proteins and their annotated locations for XP_009296380.1

    UniProtKB/TrEMBL
    A0A8M3AZS7
    Conserved Domains (4) summary
    cd00992
    Location:50 → 156
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:1031 → 1227
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:817 → 931
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:817 → 926
    PH; PH domain

  4. XM_009298106.4 → XP_009296381.1  rho GTPase-activating protein 21 isoform X5

    See identical proteins and their annotated locations for XP_009296381.1

    UniProtKB/TrEMBL
    A0A8M3AZS7
    Conserved Domains (4) summary
    cd00992
    Location:50 → 156
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:1031 → 1227
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:817 → 931
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:817 → 926
    PH; PH domain

  5. XM_009298096.4 → XP_009296371.1  rho GTPase-activating protein 21 isoform X4

    See identical proteins and their annotated locations for XP_009296371.1

    UniProtKB/TrEMBL
    A0A8M3AWP2
    Conserved Domains (3) summary
    cd04395
    Location:827 → 1023
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:613 → 727
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:613 → 722
    PH; PH domain

  6. XM_068213590.1 → XP_068069691.1  rho GTPase-activating protein 21 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools