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RpS19a Ribosomal protein S19a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32635, updated on 4-Jan-2025

Summary

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Official Symbol
RpS19aprovided by FlyBase
Official Full Name
Ribosomal protein S19aprovided by FlyBase
Primary source
FLYBASE:FBgn0010412
Locus tag
Dmel_CG4464
See related
AllianceGenome:FB:FBgn0010412
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GM26647; CG4464; Dmel\CG4464; Rp S19a; rpS19; RpS19; RPS19a; S19; S19a; S19e
Summary
A structural constituent of ribosome. Predicted to be involved in ribosomal small subunit assembly. Located in cytosolic ribosome. Is expressed in adult head. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia and Diamond-Blackfan anemia 1. Orthologous to human RPS19 (ribosomal protein S19). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See RpS19a in Genome Data Viewer
Location:
14F4-14F4; 1-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16637894..16639249)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16531927..16533282)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rho kinase Neighboring gene antisense RNA:CR45001 Neighboring gene stem-bulge RNA 1 Neighboring gene Small nuclear ribonucleoprotein G Neighboring gene methuselah-like 1 Neighboring gene long non-coding RNA:CR46147

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila ribosomal protein S19 cDNA sequence. Baumgartner S, et al. Nucleic Acids Res, 1993 Aug 11. PMID 8367309, Free PMC Article
  2. The haplolethal gene wupA of Drosophila exhibits potential as a target for an X-poisoning gene drive. Lawler CD, et al. G3 (Bethesda), 2024 Apr 3. PMID 38306583, Free PMC Article
  3. Changes in the expression of genes involved in protein synthesis during Drosophila aging. Shikama N, et al. Gerontology, 1996. PMID 8796371
  4. Spliceosome malfunction causes neurodevelopmental disorders with overlapping features. Li D, et al. J Clin Invest, 2024 Jan 2. PMID 37962958, Free PMC Article
  5. Eukaryotic ribosomal protein RPS25 interacts with the conserved loop region in a dicistroviral intergenic internal ribosome entry site. Nishiyama T, et al. Nucleic Acids Res, 2007. PMID 17287295, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation TAS
Traceable Author Statement
more info
 PubMed 
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosolic ribosome HDA PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit TAS
Traceable Author Statement
more info
 PubMed 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal protein S19a
Names
CG4464-PA
CG4464-PB
CG4464-PC
CG4464-PD
CG4464-PE
RpS19a-PA
RpS19a-PB
RpS19a-PC
RpS19a-PD
RpS19a-PE
ribosomal protein S19

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16637894..16639249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298409.1 → NP_001285338.1  ribosomal protein S19a, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285338.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4N1, B7Z0Y8, P39018, Q9VXE1
    UniProtKB/TrEMBL
    E2QD65
    Conserved Domains (1) summary
    pfam01090
    Location:5 → 139
    Ribosomal_S19e; Ribosomal protein S19e

  2. NM_167527.3 → NP_727993.1  ribosomal protein S19a, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4N1, B7Z0Y8, P39018, Q9VXE1
    UniProtKB/TrEMBL
    E2QD65
    Related
    FBpp0074088
    Conserved Domains (1) summary
    pfam01090
    Location:5 → 139
    Ribosomal_S19e; Ribosomal protein S19e

  3. NM_167526.3 → NP_727992.1  ribosomal protein S19a, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727992.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4N1, B7Z0Y8, P39018, Q9VXE1
    UniProtKB/TrEMBL
    E2QD65
    Related
    FBpp0074087
    Conserved Domains (1) summary
    pfam01090
    Location:5 → 139
    Ribosomal_S19e; Ribosomal protein S19e

  4. NM_078652.4 → NP_523376.1  ribosomal protein S19a, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523376.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4N1, B7Z0Y8, P39018, Q9VXE1
    UniProtKB/TrEMBL
    E2QD65
    Related
    FBpp0074086
    Conserved Domains (1) summary
    pfam01090
    Location:5 → 139
    Ribosomal_S19e; Ribosomal protein S19e

  5. NM_001298410.1 → NP_001285339.1  ribosomal protein S19a, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285339.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4N1, B7Z0Y8, P39018, Q9VXE1
    UniProtKB/TrEMBL
    E2QD65
    Conserved Domains (1) summary
    pfam01090
    Location:5 → 139
    Ribosomal_S19e; Ribosomal protein S19e
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2QD65 E2QD65
P39018.3 P39018

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