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MtnD Metallothionein D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326270, updated on 9-Dec-2024

Summary

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Official Symbol
MtnDprovided by FlyBase
Official Full Name
Metallothionein Dprovided by FlyBase
Primary source
FLYBASE:FBgn0053192
Locus tag
Dmel_CG33192
See related
AllianceGenome:FB:FBgn0053192
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33192; Dmel\CG33192; MT; mtnD; MTND
Summary
Enables metal ion binding activity. Involved in cellular detoxification of metal ion and response to copper ion. Is expressed in embryonic/larval copper cell; embryonic/larval midgut; and larval iron accumulating cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See MtnD in Genome Data Viewer
Location:
92F1-92F1; 3-69 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20534962..20535301)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16360684..16361023)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Major Facilitator Superfamily Transporter 9 Neighboring gene Signal-transducer and activator of transcription protein at 92E Neighboring gene Metallothionein E Neighboring gene alternative testis transcripts open reading frame B Neighboring gene Dephosphocoenzyme A carrier

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences. Kappeler M, et al. Nucleic Acids Res, 2008 Dec. PMID 18978019, Free PMC Article
  2. Is MtnE, the fifth Drosophila metallothionein, functionally distinct from the other members of this polymorphic protein family? Pérez-Rafael S, et al. Metallomics, 2012 Apr. PMID 22370740
  3. An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variation and Local Adaptation in Drosophila melanogaster. Catalán A, et al. PLoS Genet, 2016 Apr. PMID 27120580, Free PMC Article
  4. Metallothioneins and resistance to cadmium poisoning in Drosophila cells. Debec A, et al. Biochem Biophys Res Commun, 1985 Feb 28. PMID 3919723
  5. Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis. Egli D, et al. EMBO J, 2003 Jan 2. PMID 12505988, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular detoxification of metal ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to copper ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to metal ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to metal ion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
metallothionein D
Names
CG33192-PB
MtnD-PB
metallothionein
NP_788695.2
  • point mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20534962..20535301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176518.2 → NP_788695.2  metallothionein D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788695.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1WW94, Q86B88, Q8I9B4
    Conserved Domains (1) summary
    pfam02067
    Location:1 → 41
    Metallothio_5; Metallothionein family 5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8I9B4.1 Q8I9B4

Gene LinkOut

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