para - paralytic

Enables voltage-gated sodium channel activity. Involved in several processes, including male courtship behavior, veined wing generated song production; mechanosensory behavior; and sodium ion transmembrane transport. Located in plasma membrane. Is expressed in adult brain; adult brain cell body rind; adult ventral nerve cord; and eye. Used to study Dravet syndrome; epilepsy; generalized epilepsy with febrile seizures plus; and generalized epilepsy with febrile seizures plus 2. Human ortholog(s) of this gene implicated in several diseases, including congenital myopathy (multiple); epilepsy (multiple); heart conduction disease (multiple); intrinsic cardiomyopathy (multiple); and neuropathy (multiple). Orthologous to several human genes including SCN3A (sodium voltage-gated channel alpha subunit 3). [provided by Alliance of Genome Resources, Dec 2024]

NCBI Orthologs

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