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Adi1 Acireductone dioxygenase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326189, updated on 9-Dec-2024

Summary

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Official Symbol
Adi1provided by FlyBase
Official Full Name
Acireductone dioxygenase 1provided by FlyBase
Primary source
FLYBASE:FBgn0052068
Locus tag
Dmel_CG32068
See related
AllianceGenome:FB:FBgn0052068
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
adi1; CG32068; CG8000; Dadi1; Dmel\CG32068
Summary
Predicted to enable acireductone dioxygenase [iron(II)-requiring] activity. Involved in methionine biosynthetic process and positive regulation of reproductive process. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Is expressed in adult head and organism. Orthologous to human ADI1 (acireductone dioxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Adi1 in Genome Data Viewer
Location:
67E6-67E6; 3-33 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10663376..10664435)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10656476..10657535)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene simjang Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ADI1, a methionine salvage pathway enzyme, is required for Drosophila fecundity. Chou HY, et al. J Biomed Sci, 2014 Jul 19. PMID 25037729, Free PMC Article
  2. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
  3. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047, Free PMC Article
  4. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article
  5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acireductone dioxygenase [iron(II)-requiring] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acireductone dioxygenase [iron(II)-requiring] activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in L-methionine salvage from methylthioadenosine IEA
Inferred from Electronic Annotation
more info
  
involved_in L-methionine salvage from methylthioadenosine ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in methionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methionine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
acireductone dioxygenase 1
Names
Adi1-PB
CG32068-PB
aci-reductone dioxygenase 1
NP_001097577.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    10663376..10664435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104107.2 → NP_001097577.1  acireductone dioxygenase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097577.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6AWN0, Q8IQE4
    UniProtKB/TrEMBL
    F3YDM3
    Conserved Domains (1) summary
    cl21464
    Location:3 → 158
    cupin_like; Conserved domain found in cupin and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AWN0.2 Q6AWN0

Gene LinkOut

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Chemical Information
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