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scramb1 scramblase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326186, updated on 4-Jan-2025

Summary

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Official Symbol
scramb1provided by FlyBase
Official Full Name
scramblase 1provided by FlyBase
Primary source
FLYBASE:FBgn0052056
Locus tag
Dmel_CG32056
See related
AllianceGenome:FB:FBgn0052056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32056; CG6590; CT20492; Dmel\CG32056; Scramb1
Summary
Predicted to enable phospholipid scramblase activity. Involved in chemical synaptic transmission. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; adult heart; garland cell; and garland cell primordium. Orthologous to several human genes including PLSCR1 (phospholipid scramblase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See scramb1 in Genome Data Viewer
Location:
67D11-67D11; 3-32 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10220483..10225240, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10213583..10218340, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44542 Neighboring gene long non-coding RNA:CR45403

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila melanogaster Scramblases modulate synaptic transmission. Acharya U, et al. J Cell Biol, 2006 Apr 10. PMID 16606691, Free PMC Article
  2. The coagulation of insect hemolymph. Theopold U, et al. Cell Mol Life Sci, 2002 Feb. PMID 11915949, Free PMC Article
  3. Phospholipid scramblase 1: an essential component of the nephrocyte slit diaphragm. Castillo-Mancho V, et al. Cell Mol Life Sci, 2024 Jun 15. PMID 38878170, Free PMC Article
  4. A humoral stress response protects Drosophila tissues from antimicrobial peptides. Rommelaere S, et al. Curr Biol, 2024 Apr 8. PMID 38484734
  5. Identification of neural outgrowth genes using genome-wide RNAi. Sepp KJ, et al. PLoS Genet, 2008 Jul 4. PMID 18604272, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phospholipid scramblase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid scramblase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane phospholipid scrambling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane phospholipid scrambling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
scramblase 1
Names
CG32056-PA
CG32056-PB
CG32056-PC
scramb1-PA
scramb1-PB
scramb1-PC
scramblase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    10220483..10225240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168404.2 → NP_729601.1  scramblase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729601.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQD7
    Related
    FBpp0076031
    Conserved Domains (1) summary
    pfam03803
    Location:1 → 221
    Scramblase

  2. NM_140132.3 → NP_648389.3  scramblase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648389.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TV8, Q9VT88
    Conserved Domains (2) summary
    pfam03803
    Location:184 → 404
    Scramblase; Scramblase
    pfam12067
    Location:61 → 129
    Sox_C_TAD; Sox C-terminal transactivation domain

  3. NM_168403.2 → NP_729600.1  scramblase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729600.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQD8
    Related
    FBpp0076032
    Conserved Domains (1) summary
    pfam03803
    Location:101 → 320
    Scramblase; Scramblase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQD7 Q8IQD7
Q8IQD8 Q8IQD8
Q9VT88 Q9VT88

Gene LinkOut

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