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CG32052 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326184, updated on 9-Dec-2024

Summary

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Official Symbol
CG32052provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0044328
Locus tag
Dmel_CG32052
See related
AllianceGenome:FB:FBgn0044328
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aSMase; BEST:HL01355; CG8163; Dmel\CG32052; Smase
Summary
Predicted to enable phosphoric diester hydrolase activity. Predicted to be active in extracellular space. Is expressed in adult head and embryonic head sensory system. Orthologous to several human genes including SMPDL3B (sphingomyelin phosphodiesterase acid like 3B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG32052 in Genome Data Viewer
Location:
67C8-67C9; 3-31 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9787046..9808713)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9792162..9801813)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45407 Neighboring gene Anion exchanger 2 Neighboring gene Z band alternatively spliced PDZ-motif protein 67 Neighboring gene Insulin-like peptide 1 Neighboring gene Insulin-like peptide 2 Neighboring gene Insulin-like peptide 3 Neighboring gene Insulin-like peptide 4 Neighboring gene uncharacterized protein Neighboring gene Insulin-like peptide 5 Neighboring gene Inhibitor-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila simulans - Ilp2. Laskowski LF, et al. MicroPubl Biol, 2022. PMID 36468154, Free PMC Article
  2. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Brogiolo W, et al. Curr Biol, 2001 Feb 20. PMID 11250149
  3. Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila. Chen X, et al. Natl Sci Rev, 2022 Dec. PMID 36713590, Free PMC Article
  4. Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities. Zhang H, et al. Proc Natl Acad Sci U S A, 2009 Nov 17. PMID 19887630, Free PMC Article
  5. Sex- and segment-specific modulation of gene expression profiles in Drosophila. Barmina O, et al. Dev Biol, 2005 Dec 15. PMID 16269142

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoric diester hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT enables sphingomyelin phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG32052-PC
CG32052-PD
CG32052-PE
NP_001303410.1
NP_001303411.1
NP_729555.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9787046..9808713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316482.1 → NP_001303411.1  uncharacterized protein Dmel_CG32052, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQD3
    Conserved Domains (1) summary
    cd00842
    Location:28 → 351
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain

  2. NM_001316481.1 → NP_001303410.1  uncharacterized protein Dmel_CG32052, isoform D [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQD3
    Conserved Domains (1) summary
    cd00842
    Location:28 → 351
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain

  3. NM_168375.5 → NP_729555.4  uncharacterized protein Dmel_CG32052, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729555.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQD3
    Conserved Domains (1) summary
    cd00842
    Location:28 → 351
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQD3 Q8IQD3
Q8MSD7 Q8MSD7

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