U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Npc2e Niemann-Pick type C-2e [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326136, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Npc2eprovided by FlyBase
Official Full Name
Niemann-Pick type C-2eprovided by FlyBase
Primary source
FLYBASE:FBgn0051410
Locus tag
Dmel_CG31410
See related
AllianceGenome:FB:FBgn0051410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31410; CG3928; Dmel\CG31410; npc2e
Summary
Enables several functions, including lipopolysaccharide binding activity; lipoteichoic acid binding activity; and peptidoglycan binding activity. Involved in positive regulation of defense response to bacterium. Located in extracellular space. Is expressed in embryonic/larval midgut. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Npc2e in Genome Data Viewer
Location:
85F8-85F8; 3-49 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10053332..10054348)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5879054..5880070)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitochondrial transcription factor B2 Neighboring gene uncharacterized protein Neighboring gene ohgata Neighboring gene antisense RNA:CR44192 Neighboring gene fancl Neighboring gene Niemann-Pick type C-2d Neighboring gene antisense RNA:CR45205 Neighboring gene Niemann-Pick type C-2c

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis. Horner MA, et al. Genes Dev, 2009 Dec 1. PMID 19952106, Free PMC Article
  2. Drosophila melanogaster NPC2 proteins bind bacterial cell wall components and may function in immune signal pathways. Shi XZ, et al. Insect Biochem Mol Biol, 2012 Aug. PMID 22580186, Free PMC Article
  3. Drosophila Niemann-Pick type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease. Huang X, et al. Development, 2007 Oct. PMID 17804599
  4. Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease. Garrido-Maraver J, et al. Biol Open, 2020 Jan 14. PMID 31822473, Free PMC Article
  5. The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. Sieber MH, et al. Cell Metab, 2009 Dec. PMID 19945405, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipid antigen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipoteichoic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sterol binding IEA
Inferred from Electronic Annotation
more info
  
enables sterol binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of defense response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sterol transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Niemann-Pick type C-2e
Names
CG31410-PB
Npc2e-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10053332..10054348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169323.3 → NP_731439.2  Niemann-Pick type C-2e [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731439.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D9PTV0, Q9VH33
    Conserved Domains (1) summary
    cl00274
    Location:20 → 144
    ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VH33 Q9VH33

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools