PH4alphaSG1 prolyl-4-hydroxylase-alpha SG1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PH4alphaSG1provided by FlyBase
Official Full Name: prolyl-4-hydroxylase-alpha SG1provided by FlyBase
Primary source: FLYBASE:FBgn0051014
Locus tag: Dmel_CG31014
See related: AllianceGenome:FB:FBgn0051014
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alphaSG1; CG15542; CG31014; Dmel\CG31014; Ph4alphaSG1; PH4aSG1; PHalphaSG1; SG1
Summary: Predicted to enable procollagen-proline 4-dioxygenase activity. Involved in salivary gland morphogenesis. Located in endoplasmic reticulum. Is expressed in gland; presumptive embryonic salivary gland; salivary gland body primordium; and visceral mesoderm derivative. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30503665..30505661, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (26329387..26331383, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression of PH4alphaSG1 was indirectly regulated by Fkh and Sage.
Title: Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2.

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Function	Evidence Code	Pubs
enables L-ascorbic acid binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables procollagen-proline 4-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables procollagen-proline 4-dioxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in collagen fibril organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

Names: CG31014-PA; PH4alphaSG1-PA; SG specific ER protein prolyl-4-hydroxylase; prolyl 4-hydroxylase alpha salivary gland 1

NP_733376.1

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The following sections contain reference sequences that belong to a specific genome build. Explain