mei-41 meiotic 41 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mei-41provided by FlyBase
Official Full Name: meiotic 41provided by FlyBase
Primary source: FLYBASE:FBgn0004367
Locus tag: Dmel_CG4252
See related: AllianceGenome:FB:FBgn0004367
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 4252; atr; ATR; CG4252; dATR; DmATR; Dmel\CG4252; Dmmei41; fs(1)M37; mei-195; Mei-41; Mei-41/DATR; mei41; Mei41; MEI41; MEI41/FRP1; meiP41; mus(1)103; mus(1)104; mus-103; mus-104; mus103; mus104
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including DNA metabolic process; female meiosis chromosome segregation; and regulation of cell cycle process. Predicted to be active in chromosome and nucleus. Is expressed in ovary. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic cancer. Orthologous to human ATR (ATR serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 14C3-14C3; 1-53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (16391698..16399850)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (16285731..16293883)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts.
Title: Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts.
The authors propose that ATR/Chk1 negatively regulate G2-M in developing tracheoblasts and that G2 arrest facilitates cellular and hypertrophic organ growth.
Title: Negative regulation of G2-M by ATR (mei-41)/Chk1(Grapes) facilitates tracheoblast growth and tracheal hypertrophy in Drosophila.
Overexpression of the Drosophila ATR homologue mei-41 elicits an effectual DNA damage response irrespective of irradiation.
Title: Overexpression of the Drosophila ATR homologous checkpoint kinase Mei-41 induces a G2/M checkpoint in Drosophila imaginal tissue.
our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.
Title: Requirement of ATR for maintenance of intestinal stem cells in aging Drosophila.
Drosophila ATR has distinct activities in the regulation of meiotic DNA damage and repair
Title: Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair.
A significant component of the defects in the later steps of DNA homologous recombination repair are due to loss of MEI-41-dependent cell cycle regulation.
Title: Drosophila ATR in double-strand break repair.
Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.
Title: Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance.
Mutations in the ATR/Chk2 DNA damage signal transduction pathway dramatically suppress these axis specification defects, but do not restore retrotransposon or Stellate silencing.
Title: Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response.
MEI-41 acts not in a single rigid signal transduction pathway, but in multiple molecular contexts to carry out its many functions
Title: Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage checkpoint signaling	TAS Traceable Author Statement more info	PubMed
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellularization	TAS Traceable Author Statement more info	PubMed
involved_in chromosome condensation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via single-strand annealing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via synthesis-dependent strand annealing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic development via the syncytial blastoderm	TAS Traceable Author Statement more info	PubMed
involved_in female meiosis chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc development	TAS Traceable Author Statement more info	PubMed
involved_in meiotic DNA double-strand break processing	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic DNA replication checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic nuclear division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of syncytial blastoderm mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in response to radiation	TAS Traceable Author Statement more info	PubMed
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: meiotic 41

Names: ATM-RAD3 related; CG4252-PA; ataxia telangiectasia and Rad3 related; drosophila ATR; mei-41-PA; meiotic-41

NP_523369.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

16391698..16399850

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078645.3 → NP_523369.2 meiotic 41 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523369.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24135, Q9VXG8

Related

FBpp0074047

Conserved Domains (4) summary

smart00802
Location:955 → 1060

UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1

cd00892
Location:2181 → 2448

PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins

pfam02259
Location:1653 → 1985

FAT; FAT domain

pfam02260
Location:2486 → 2517

FATC; FATC domain