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prkg3 protein kinase cGMP-dependent 3 [ Danio rerio (zebrafish) ]

Gene ID: 326020, updated on 4-Jan-2025

Summary

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Official Symbol
prkg3provided by ZNC
Official Full Name
protein kinase cGMP-dependent 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4745
See related
Ensembl:ENSDARG00000014232 AllianceGenome:ZFIN:ZDB-GENE-030131-4745
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fd58b04; wu:fd58b04; si:dkey-121j17.5
Summary
Predicted to enable ATP binding activity; cGMP binding activity; and cGMP-dependent protein kinase activity. Predicted to act upstream of or within protein phosphorylation. Is expressed in gall bladder; intestine; kidney; ovary; and testis. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See prkg3 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (616095..650120, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (640653..657207, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 2b Neighboring gene potassium channel, subfamily K, member 2b Neighboring gene uncharacterized LOC137488606 Neighboring gene neural retina leucine zipper Neighboring gene SUMO specific peptidase 6a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The role of PKG in oocyte maturation of zebrafish. Li J, et al. Biochem Biophys Res Commun, 2018 Oct 28. PMID 30269816
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cGMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cGMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cGMP-dependent protein kinase 1; cGMP-dependent protein kinase 1-like
XP_017208033.3
XP_021324230.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    616095..650120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017352544.3 → XP_017208033.3  cGMP-dependent protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z2R2

  2. XM_021468555.2 → XP_021324230.1  cGMP-dependent protein kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z2R2, A0A8M9PT30
    Related
    ENSDARP00000020894.5, ENSDART00000017857.7
    Conserved Domains (2) summary
    cd00038
    Location:107 → 216
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:378 → 633
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
Nucleotide Protein Strain
Heading Accession and Version

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Molecular Biology Databases
Research Materials