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Had1 beta Hydroxy acid dehydrogenase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32592, updated on 4-Jan-2025

Summary

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Official Symbol
Had1provided by FlyBase
Official Full Name
beta Hydroxy acid dehydrogenase 1provided by FlyBase
Primary source
FLYBASE:FBgn0286508
Locus tag
Dmel_CG9914
See related
AllianceGenome:FB:FBgn0286508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9914; CRYL1; Dmel\CG9914; Had; HAD
Summary
Enables L-gulonate 3-dehydrogenase activity. Predicted to be involved in D-glucuronate catabolic process to D-xylulose 5-phosphate. Predicted to be active in cytosol. Is expressed in adult head and adult heart. Orthologous to human CRYL1 (crystallin lambda 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Had1 in Genome Data Viewer
Location:
14B9-14B9; 1-53 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16306912..16308667, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16200945..16202700, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene cabeza Neighboring gene Endoplasmic reticulum protein 44 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45485 Neighboring gene uncharacterized protein Neighboring gene Strumpellin and WASH-interacting protein Neighboring gene Cyclophilin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetics and physiological expression of beta-hydroxy acid dehydrogenase in Drosophila. Tobler JE, et al. Biochem Genet, 1978 Apr. PMID 28119
  2. Drosophila beta-L-hydroxy acid dehydrogenase. Purification and properties. Borack LI, et al. J Biol Chem, 1971 Sep 10. PMID 4328697
  3. Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. Silva B, et al. Nat Metab, 2022 Feb. PMID 35177854, Free PMC Article
  4. Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. Terhzaz S, et al. J Biol Chem, 2006 Jul 7. PMID 16670086
  5. Cis-regulatory variation is typically polyallelic in Drosophila. Gruber JD, et al. Genetics, 2009 Feb. PMID 19064705, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-gulonate 3-dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-gulonate 3-dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-gulonate 3-dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
beta hydroxy acid dehydrogenase 1
Names
3-hydroxyacyl-CoA dehydrogenase
B-L-hydroxy acid dehydrogenase
CG9914-PA
CG9914-PB
Enoyl-CoA hydratase mitochondrial
Had1-PA
Had1-PB
beta hydroxy acid dehydrogenase
beta-L-hydroxy acid dehydrogenase
beta-hydroxy acid dehydrogenase
NP_001285320.1
NP_573114.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16306912..16308667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298391.1 → NP_001285320.1  beta hydroxy acid dehydrogenase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285320.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU75, Q9VXI1
    Conserved Domains (3) summary
    PRK06129
    Location:7 → 310
    PRK06129; 3-hydroxyacyl-CoA dehydrogenase; Validated
    pfam00725
    Location:191 → 265
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:7 → 183
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

  2. NM_132886.3 → NP_573114.2  beta hydroxy acid dehydrogenase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573114.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU75, Q9VXI1
    Related
    FBpp0074019
    Conserved Domains (3) summary
    PRK06129
    Location:7 → 310
    PRK06129; 3-hydroxyacyl-CoA dehydrogenase; Validated
    pfam00725
    Location:191 → 265
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:7 → 183
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXI1 Q9VXI1

Gene LinkOut

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