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mmd mind-meld [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32561, updated on 4-Jan-2025

Summary

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Official Symbol
mmdprovided by FlyBase
Official Full Name
mind-meldprovided by FlyBase
Primary source
FLYBASE:FBgn0259110
Locus tag
Dmel_CG42252
See related
AllianceGenome:FB:FBgn0259110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15603; CG15604; CG42252; CG9163; CT26192; Dmel\CG42252
Old locus tag
Dmel_CG15603; Dmel_CG15604; Dmel_CG9163
Summary
Predicted to be located in membrane. Is expressed in adult head; dorsal head epidermis; embryonic brain; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Orthologous to several human genes including ADAM22 (ADAM metallopeptidase domain 22) and ADAM23 (ADAM metallopeptidase domain 23). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See mmd in Genome Data Viewer
Location:
14A1-14A4; 1-52 cM
Exon count:
28
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15946936..15973159, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15840969..15867192, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribosomal RNA processing 47 Neighboring gene mir-927 stem loop Neighboring gene long non-coding RNA:CR45527 Neighboring gene Odorant receptor 13a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome. Sanfilippo P, et al. Neuron, 2024 Mar 20. PMID 38262414,
  2. Drosophila metalloproteases in development and differentiation: the role of ADAM proteins and their relatives. Meyer H, et al. Eur J Cell Biol, 2011 Sep. PMID 21684629
  3. Drosophila in asthma research. Roeder T, et al. Am J Respir Crit Care Med, 2009 Jun 1. PMID 19342413
  4. The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning. Hull R, et al. Int J Mol Sci, 2015 May 6. PMID 25955646, Free PMC Article
  5. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Mukherjee C, et al. Cell Metab, 2020 Aug 4. PMID 32531201, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
Process Evidence Code Pubs
NOT involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
mind-meld
Names
CG42252-PB
CG42252-PD
CG42252-PE
CG42252-PF
CG42252-PG
CG42252-PH
CG42252-PI
CG42252-PJ
Meltrin-like
Mind-meld
mind meld
mmd-PB
mmd-PD
mmd-PE
mmd-PF
mmd-PG
mmd-PH
mmd-PI
mmd-PJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15946936..15973159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258776.2 → NP_001245705.1  mind-meld, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245705.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDY9
    Conserved Domains (5) summary
    smart00608
    Location:566 → 713
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:270 → 471
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:488 → 562
    Disintegrin; Disintegrin
    pfam01421
    Location:270 → 473
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:106 → 213
    Pep_M12B_propep; Reprolysin family propeptide

  2. NM_001272662.2 → NP_001259591.1  mind-meld, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259591.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PH86
    Conserved Domains (5) summary
    smart00608
    Location:566 → 713
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:270 → 471
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:488 → 562
    Disintegrin; Disintegrin
    pfam01421
    Location:270 → 473
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:106 → 213
    Pep_M12B_propep; Reprolysin family propeptide

  3. NM_001272661.2 → NP_001259590.1  mind-meld, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259590.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PER2
    Conserved Domains (5) summary
    smart00608
    Location:566 → 713
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:270 → 471
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:488 → 562
    Disintegrin; Disintegrin
    pfam01421
    Location:270 → 473
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:106 → 213
    Pep_M12B_propep; Reprolysin family propeptide

  4. NM_078634.7 → NP_523358.5  mind-meld, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523358.5

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXL1
    Conserved Domains (5) summary
    smart00608
    Location:566 → 713
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:270 → 471
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:488 → 562
    Disintegrin; Disintegrin
    pfam01421
    Location:270 → 473
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:106 → 213
    Pep_M12B_propep; Reprolysin family propeptide

  5. NM_001298382.1 → NP_001285311.1  mind-meld, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285311.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JE21
    Conserved Domains (5) summary
    smart00608
    Location:566 → 713
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:270 → 471
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:488 → 562
    Disintegrin; Disintegrin
    pfam01421
    Location:270 → 473
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:106 → 213
    Pep_M12B_propep; Reprolysin family propeptide

  6. NM_001144728.3 → NP_001138200.1  mind-meld, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138200.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0Y2
    Conserved Domains (5) summary
    smart00608
    Location:566 → 713
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:270 → 471
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:488 → 562
    Disintegrin; Disintegrin
    pfam01421
    Location:270 → 473
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:106 → 213
    Pep_M12B_propep; Reprolysin family propeptide

  7. NM_001258775.3 → NP_001245704.1  mind-meld, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245704.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NH46
    Conserved Domains (5) summary
    smart00608
    Location:566 → 713
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:270 → 471
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:488 → 562
    Disintegrin; Disintegrin
    pfam01421
    Location:270 → 473
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:106 → 213
    Pep_M12B_propep; Reprolysin family propeptide

  8. NM_206752.3 → NP_996475.2  mind-meld, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996475.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KUY7, Q9GZ15
    Conserved Domains (5) summary
    smart00608
    Location:566 → 713
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:270 → 471
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:488 → 562
    Disintegrin; Disintegrin
    pfam01421
    Location:270 → 473
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:106 → 213
    Pep_M12B_propep; Reprolysin family propeptide
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z0Y2 B7Z0Y2
M9NDY9 M9NDY9
M9NH46 M9NH46
M9PER2 M9PER2
M9PH86 M9PH86
Q7KUY7 Q7KUY7
Q9GZ15 Q9GZ15
Q9VXL1 Q9VXL1
X2JE21 X2JE21

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