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sppl2 signal peptide peptidase-like 2 [ Danio rerio (zebrafish) ]

Gene ID: 325540, updated on 9-Dec-2024

Summary

Official Symbol
sppl2provided by ZNC
Official Full Name
signal peptide peptidase-like 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4265
See related
Ensembl:ENSDARG00000030448 AllianceGenome:ZFIN:ZDB-GENE-030131-4265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
SPPL2B; wu:fc16e01; wu:fc85d12; zgc:136525
Summary
Predicted to enable aspartic endopeptidase activity, intramembrane cleaving. Acts upstream of or within negative regulation of coagulation. Predicted to be located in endosome membrane. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Orthologous to human SPPL2B (signal peptide peptidase like 2B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See sppl2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37480654..37503009)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37498197..37520552)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:dkey-127k13.1 Neighboring gene death-associated protein kinase 3 Neighboring gene rho/rac guanine nucleotide exchange factor (GEF) 18a Neighboring gene insulin receptor a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in membrane protein proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi-associated vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in lumenal side of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
signal peptide peptidase-like 2
Names
signal peptide peptidase-like protein 2
NP_001038709.2
XP_021334581.1
XP_021334586.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045244.2NP_001038709.2  signal peptide peptidase-like 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    BX539340, EH550022, EH571140
    UniProtKB/TrEMBL
    A0A8M1NA84, F1QYI0
    Related
    ENSDARP00000032543.4, ENSDART00000029801.6
    Conserved Domains (2) summary
    cd02129
    Location:37156
    PA_hSPPL_like; PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the ...
    pfam04258
    Location:206497
    Peptidase_A22B; Signal peptide peptidase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    37480654..37503009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478906.2XP_021334581.1  signal peptide peptidase-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QFX8
    Conserved Domains (2) summary
    cd02129
    Location:37156
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:206471
    Peptidase_A22B; Signal peptide peptidase
  2. XM_021478911.2XP_021334586.1  signal peptide peptidase-like 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QFY1
    Conserved Domains (2) summary
    cd02129
    Location:37156
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:206497
    Peptidase_A22B; Signal peptide peptidase

RNA

  1. XR_224754.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001015067.1: Suppressed sequence

    Description
    NM_001015067.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.