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vamp5 vesicle-associated membrane protein 5 [ Danio rerio (zebrafish) ]

Gene ID: 325484, updated on 4-Jan-2025

Summary

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Official Symbol
vamp5provided by ZNC
Official Full Name
vesicle-associated membrane protein 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4209
See related
Ensembl:ENSDARG00000068262 AllianceGenome:ZFIN:ZDB-GENE-030131-4209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc83b05; wu:fc83b05; si:dkeyp-86b9.2
Summary
Predicted to enable SNAP receptor activity and syntaxin-1 binding activity. Predicted to be involved in SNARE complex assembly. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in plasma membrane. Orthologous to human VAMP5 (vesicle associated membrane protein 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See vamp5 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (28297210..28307473)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (27697057..27707320)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-86b9.5 Neighboring gene vesicle-associated membrane protein 8 (endobrevin) Neighboring gene dynein axonemal heavy chain 10 Neighboring gene NMDA receptor synaptonuclear signaling and neuronal migration factor b Neighboring gene leukotriene B4 receptor 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System. Zhu Y, et al. Cell, 2019 Sep 19. PMID 31495570, Free PMC Article
  2. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SNARE complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vesicle-associated membrane protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256606.1 → NP_001243535.1  vesicle-associated membrane protein 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    BX323557
    UniProtKB/TrEMBL
    A0A8M1NZ07, A2BG37
    Related
    ENSDARP00000089406.3, ENSDART00000098635.4
    Conserved Domains (2) summary
    cd15872
    Location:5 → 72
    R-SNARE_VAMP5; SNARE motif of VAMP5
    pfam00957
    Location:4 → 92
    Synaptobrevin; Synaptobrevin

  2. NM_001256607.1 → NP_001243536.1  vesicle-associated membrane protein 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BX323557
    UniProtKB/TrEMBL
    A0A8M1P4H5, A2BG36
    Related
    ENSDARP00000122979.1, ENSDART00000139862.2
    Conserved Domains (2) summary
    cd15872
    Location:4 → 71
    R-SNARE_VAMP5; SNARE motif of VAMP5
    pfam00957
    Location:3 → 91
    Synaptobrevin; Synaptobrevin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    28297210..28307473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394578.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    176515..184949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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