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sordd1 suppression of retinal degeneration disease 1 upon overexpression 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32532, updated on 4-Jan-2025

Summary

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Official Symbol
sordd1provided by FlyBase
Official Full Name
suppression of retinal degeneration disease 1 upon overexpression 1provided by FlyBase
Primary source
FLYBASE:FBgn0030693
Locus tag
Dmel_CG8974
See related
AllianceGenome:FB:FBgn0030693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8974; Dmel\CG8974
Summary
Enables ubiquitin protein ligase activity. Involved in positive regulation of ubiquitin-dependent protein catabolic process and protein ubiquitination. Is active in endoplasmic reticulum. Is expressed in several structures, including adult head; ganglia; gut section; and larval muscle system. Orthologous to human RNF185 (ring finger protein 185). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See sordd1 in Genome Data Viewer
Location:
13E18-13F1; 1-51 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15793721..15796028, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15687754..15690061, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S30 Neighboring gene Rhophilin Neighboring gene pseudo Neighboring gene suppression of retinal degeneration disease 1 upon overexpression 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suppression of retinal degeneration by two novel ERAD ubiquitin E3 ligases SORDD1/2 in Drosophila. Xu J, et al. PLoS Genet, 2020 Nov. PMID 33137101, Free PMC Article
  2. PERK prevents rhodopsin degradation during retinitis pigmentosa by inhibiting IRE1-induced autophagy. Zhao N, et al. J Cell Biol, 2023 May 1. PMID 37022709, Free PMC Article
  3. Intrinsic maturation of sleep output neurons regulates sleep ontogeny in Drosophila. Gong NN, et al. Curr Biol, 2022 Sep 26. PMID 35985328, Free PMC Article
  4. Synteny of orthologous genes conserved in mammals, snake, fly, nematode, and fission yeast. Trachtulec Z, et al. Mamm Genome, 2001 Mar. PMID 11252172
  5. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin-like protein conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
suppression of retinal degeneration disease 1 upon overexpression 1
Names
CG8974-PA
CG8974-PB
CG8974-PC
CG8974-PD
CG8974-PE
sordd1-PA
sordd1-PB
sordd1-PC
sordd1-PD
sordd1-PE
suppression Of retinal degeneration disease 1 upon overexpression 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15793721..15796028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206726.2 → NP_996449.1  suppression of retinal degeneration disease 1 upon overexpression 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996449.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXP1
    Conserved Domains (1) summary
    cd00162
    Location:124 → 169
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  2. NM_206725.2 → NP_996448.1  suppression of retinal degeneration disease 1 upon overexpression 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996448.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXP1
    Conserved Domains (1) summary
    cd00162
    Location:124 → 169
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  3. NM_167463.3 → NP_727897.1  suppression of retinal degeneration disease 1 upon overexpression 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727897.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXP1
    Related
    FBpp0073972
    Conserved Domains (1) summary
    cd00162
    Location:124 → 169
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  4. NM_132848.4 → NP_573076.1  suppression of retinal degeneration disease 1 upon overexpression 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573076.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXP1
    Related
    FBpp0073970
    Conserved Domains (1) summary
    cd00162
    Location:124 → 169
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  5. NM_167462.3 → NP_727896.1  suppression of retinal degeneration disease 1 upon overexpression 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727896.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXP1
    Related
    FBpp0073971
    Conserved Domains (1) summary
    cd00162
    Location:124 → 169
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXP1 Q9VXP1

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