adgrg1 adhesion G protein-coupled receptor G1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adgrg1provided by ZNC
Official Full Name: adhesion G protein-coupled receptor G1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3671
See related: Ensembl:ENSDARG00000027222 AllianceGenome:ZFIN:ZDB-GENE-030131-3671
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gpr56; fc49b10; wu:fc49b10
Summary: Predicted to enable G protein-coupled receptor activity. Acts upstream of or within glial cell development; regulation of oligodendrocyte progenitor proliferation; and swimming behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including heart; liver; nervous system; pleuroperitoneal region; and trigeminal placode. Human ortholog(s) of this gene implicated in bilateral frontoparietal polymicrogyria and bilateral perisylvian polymicrogyria. Orthologous to human ADGRG1 (adhesion G protein-coupled receptor G1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (28670464..28696569, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (28399269..28425438, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptomics and Phenotypic Analysis of gpr56 Knockout in Zebrafish.
Title: Transcriptomics and Phenotypic Analysis of gpr56 Knockout in Zebrafish.
Gpr56 as a new regulator in the development and maintenance of peripheral myelin.
Title: GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.
Gpr56 regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA
Title: The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myelination of posterior lateral line nerve axons	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within oligodendrocyte development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within peripheral nervous system myelin maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of defense response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of oligodendrocyte progenitor proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adhesion G-protein coupled receptor G1

Names: G protein-coupled receptor 56

NP_001018317.1

EC 2.7.11.25

XP_005166446.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020481.1 → NP_001018317.1 adhesion G-protein coupled receptor G1 precursor

See identical proteins and their annotated locations for NP_001018317.1

Status: PROVISIONAL

Source sequence(s)

AB193557

UniProtKB/TrEMBL

Q59I63

Related

ENSDARP00000139544.2, ENSDART00000162400.2

Conserved Domains (2) summary

pfam01825
Location:312 → 354

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:369 → 611

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

28670464..28696569 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166389.5 → XP_005166446.1 adhesion G-protein coupled receptor G1 isoform X1

UniProtKB/TrEMBL

A0A0R4IXA8, A0A8M2BDY6, F1QZM9

Related

ENSDARP00000124010.1, ENSDART00000148822.3

Conserved Domains (2) summary

pfam01825
Location:312 → 354

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:369 → 611

7tm_4; Olfactory receptor