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mh maternal haploid [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32480, updated on 4-Jan-2025

Summary

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Official Symbol
mhprovided by FlyBase
Official Full Name
maternal haploidprovided by FlyBase
Primary source
FLYBASE:FBgn0267977
Locus tag
Dmel_CG9203
See related
AllianceGenome:FB:FBgn0267977
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9203; Dmel\CG9203; fs(1)1182; fs(1)A1182
Summary
Enables metalloendopeptidase activity. Involved in UV protection and mitotic cell cycle. Located in germinal vesicle and male pronucleus. Is expressed in oocyte and testis. Human ortholog(s) of this gene implicated in Ruijs-Aalfs syndrome. Orthologous to human SPRTN (SprT-like N-terminal domain). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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Location:
13C4-13C5; 1-50 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15472804..15475400, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15366837..15369433, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Grip128 Neighboring gene ALG14, UDP-N-acetylglucosaminyltransferase subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Haploid cell cultures of Drosophila melanogaster. Debec A. Nature, 1978 Jul 20. PMID 98714
  2. Testing the Drosophila maternal haploid gene for functional divergence and a role in hybrid incompatibility. Castillo DM, et al. G3 (Bethesda), 2022 Aug 25. PMID 35876798, Free PMC Article
  3. Chimaeras of Drosophila melanogaster obtained by injection of haploid nuclei. Santamaría P, et al. Nature, 1980 Sep 11. PMID 6776407
  4. Analysis of haploid mosaics in Drosophila. Santamaria P. Dev Biol, 1983 Apr. PMID 6832473
  5. Quantitative microscopy uncovers ploidy changes during mitosis in live Drosophila embryos and their effect on nuclear size. Puah WC, et al. Biol Open, 2017 Mar 15. PMID 28108477, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MH is essential for genome integrity during embryogenesis. MH regulates Top2, possibly as a protease for the resolution of Top2-DNA intermediates.
    Title: Maternal Haploid, a Metalloprotease Enriched at the Largest Satellite Repeat and Essential for Genome Integrity in Drosophila Embryos.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in UV protection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in germinal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in male pronucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
maternal haploid
Names
CG9203-PA
fs(1)maternal haploid
mh-PA
spartan
NP_573032.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15472804..15475400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132804.2 → NP_573032.1  maternal haploid [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573032.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C5WLS7, Q9VXU6
    Related
    FBpp0073890
    Conserved Domains (2) summary
    smart00734
    Location:582 → 605
    ZnF_Rad18; Rad18-like CCHC zinc finger
    pfam10263
    Location:124 → 294
    SprT-like; SprT-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXU6 Q9VXU6

Gene LinkOut

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