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ptprna protein tyrosine phosphatase receptor type Na [ Danio rerio (zebrafish) ]

Gene ID: 324790, updated on 4-Jan-2025

Summary

Official Symbol
ptprnaprovided by ZNC
Official Full Name
protein tyrosine phosphatase receptor type Naprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3511
See related
Ensembl:ENSDARG00000058646 AllianceGenome:ZFIN:ZDB-GENE-030131-3511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
IA-2; ptprn; fc43c04; wu:fc43c04
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in insulin secretion involved in cellular response to glucose stimulus and regulation of secretion. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in transport vesicle membrane. Predicted to be active in secretory granule and synapse. Is expressed in brain. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine phosphatase receptor type N). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See ptprna in Genome Data Viewer
Location:
chromosome: 9
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (7548531..7619626)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (7570111..7641235)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 198aa Neighboring gene desmin a Neighboring gene microRNA 153c Neighboring gene DnaJ heat shock protein family (Hsp40) member B2 Neighboring gene uncharacterized LOC137496446 Neighboring gene uncharacterized LOC137496447 Neighboring gene tubulin, alpha 8 like 3

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
located_in cytoplasmic vesicle  
is_active_in secretory granule  
located_in secretory granule  
is_active_in synapse  
located_in synapse  
located_in transport vesicle membrane  

General protein information

Preferred Names
protein tyrosine phosphatase receptor type Na
Names
protein tyrosine phosphatase, receptor type, N
NP_001124060.2
XP_017213141.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130588.2NP_001124060.2  protein tyrosine phosphatase receptor type Na precursor

    Status: VALIDATED

    Source sequence(s)
    CU639452, CU861474
    UniProtKB/TrEMBL
    A0A8M1NL05, F1R8X1
    Related
    ENSDARP00000075984.4, ENSDART00000081543.5
    Conserved Domains (5) summary
    smart00194
    Location:633892
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:660892
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam10152
    Location:284370
    DUF2360; Predicted coiled-coil domain-containing protein (DUF2360)
    pfam11548
    Location:395480
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:47105
    RESP18; RESP18 domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    7548531..7619626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017357652.3XP_017213141.1  protein tyrosine phosphatase receptor type Na isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z8D6
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