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Cngl Cyclic nucleotide-gated ion channel-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32468, updated on 9-Dec-2024

Summary

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Official Symbol
Cnglprovided by FlyBase
Official Full Name
Cyclic nucleotide-gated ion channel-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0263257
Locus tag
Dmel_CG43395
See related
AllianceGenome:FB:FBgn0263257
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18210; CG43395; CG9176; cngl; CNGL; dmCNG3; Dmel\CG43395; mdcds_55060
Old locus tag
Dmel_CG18210; Dmel_CG9176
Summary
Predicted to enable intracellularly cyclic nucleotide-activated monoatomic cation channel activity. Predicted to be involved in monoatomic cation transport. Predicted to be located in membrane. Predicted to be part of intracellular cyclic nucleotide activated cation channel complex. Is expressed in several structures, including adult brain cell body rind; adult mushroom body; adult optic lobe; organism subdivision; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Cngl in Genome Data Viewer
Location:
13C1-13C1; 1-50 cM
Exon count:
21
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15386038..15441252, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15280071..15335285, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene abnormal chemosensory jump 6 Neighboring gene Protein phosphatase 1 at 13C Neighboring gene uncharacterized protein Neighboring gene scamp Neighboring gene Adenosylhomocysteinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a putative cyclic nucleotide-gated channel from Drosophila melanogaster. Miyazu M, et al. Insect Mol Biol, 2000 Jun. PMID 10886412
  2. Knockdown of a Cyclic Nucleotide-Gated Ion Channel Impairs Locomotor Activity and Recovery From Hypoxia in Adult Drosophila melanogaster. Qiu S, et al. Front Physiol, 2022. PMID 35530504, Free PMC Article
  3. PKA and cAMP/CNG Channels Independently Regulate the Cholinergic Ca(2+)-Response of Drosophila Mushroom Body Neurons. Pavot P, et al. eNeuro, 2015 Mar-Apr. PMID 26464971, Free PMC Article
  4. Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Vermehren-Schmaedick A, et al. Genetics, 2010 Sep. PMID 20592263, Free PMC Article
  5. Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. Dijkers PF, et al. Mol Biol Cell, 2009 Sep. PMID 19625446, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

mobile_element

  • Loc: c15423429-15421974 mobile_element_type = transposon:pogo{}CG18210[pogo139]
  • Loc: c15433640-15433220 mobile_element_type = transposon:INE-1{}3523

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of intracellular cyclic nucleotide activated cation channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclic nucleotide-gated ion channel-like
Names
CG43395-PD
CG43395-PE
CG43395-PF
CG43395-PI
CG43395-PJ
CG43395-PK
CNG channel-like
Cngl-PD
Cngl-PE
Cngl-PF
Cngl-PI
Cngl-PJ
Cngl-PK
cng-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15386038..15441252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258761.3 → NP_001245690.1  cyclic nucleotide-gated ion channel-like, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245690.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NGG3
    Conserved Domains (4) summary
    COG0664
    Location:535 → 665
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:541 → 653
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:245 → 466
    Ion_trans; Ion transport protein
    pfam07885
    Location:367 → 461
    Ion_trans_2; Ion channel

  2. NM_001258762.3 → NP_001245691.1  cyclic nucleotide-gated ion channel-like, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245691.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NEI3
    Conserved Domains (4) summary
    COG0664
    Location:550 → 680
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:556 → 668
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:260 → 481
    Ion_trans; Ion transport protein
    pfam07885
    Location:382 → 476
    Ion_trans_2; Ion channel

  3. NM_167441.5 → NP_727848.3  cyclic nucleotide-gated ion channel-like, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727848.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXV8
    Conserved Domains (3) summary
    COG0664
    Location:578 → 708
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:584 → 696
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:260 → 509
    Ion_trans; Ion transport protein

  4. NM_001370020.1 → NP_001356908.1  cyclic nucleotide-gated ion channel-like, isoform K [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A499NPJ3
    Conserved Domains (2) summary
    cd00038
    Location:556 → 668
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:240 → 481
    Ion_trans; Ion transport protein

  5. NM_001272642.2 → NP_001259571.2  cyclic nucleotide-gated ion channel-like, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259571.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PH69
    Conserved Domains (4) summary
    COG0664
    Location:550 → 680
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:556 → 668
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:260 → 481
    Ion_trans; Ion transport protein
    pfam07885
    Location:382 → 476
    Ion_trans_2; Ion channel

  6. NM_132794.5 → NP_573022.2  cyclic nucleotide-gated ion channel-like, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573022.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YTY7, Q9VXV7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A499NPJ3 A0A499NPJ3
M9NEI3 M9NEI3
M9NGG3 M9NGG3
M9PH69 M9PH69
Q9U5E2 Q9U5E2
Q9VXV7 Q9VXV7
Q9VXV8 Q9VXV8

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