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Lsd-2 Lipid storage droplet-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32437, updated on 4-Jan-2025

Summary

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Official Symbol
Lsd-2provided by FlyBase
Official Full Name
Lipid storage droplet-2provided by FlyBase
Primary source
FLYBASE:FBgn0030608
Locus tag
Dmel_CG9057
See related
AllianceGenome:FB:FBgn0030608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
145098_at; CG9057; Dmel\CG9057; dmPLIN2; DmPLIN2; dPlin2; LSD; lsd-2; LSD-2; lsd2; Lsd2; LSD2; LSP-2; plin2; Plin2; PLIN2
Summary
Involved in several processes, including lipid droplet formation; lipid droplet transport along microtubule; and positive regulation of sequestering of triglyceride. Located in cytosol and lipid droplet. Is expressed in several structures, including adult brain; adult brain cell body rind; epithelium; fat body; and germline cell. Used to study metabolic dysfunction-associated steatotic liver disease and obesity. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 4 and obesity. Orthologous to several human genes including PLIN1 (perilipin 1) and PLIN2 (perilipin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Lsd-2 in Genome Data Viewer
Location:
13A8-13A9; 1-49 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15069127..15076220, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14963160..14970253, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) B18 subunit Neighboring gene opossum Neighboring gene doppelganger von brummer Neighboring gene long non-coding RNA:CR44662 Neighboring gene long non-coding RNA:CR44661 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of fat storage by a Drosophila PAT domain protein. Grönke S, et al. Curr Biol, 2003 Apr 1. PMID 12676093
  2. Food memory circuits regulate eating and energy balance. Pardo-Garcia TR, et al. Curr Biol, 2023 Jan 23. PMID 36528025, Free PMC Article
  3. Ensheathing glia promote increased lifespan and healthy brain aging. Sheng L, et al. Aging Cell, 2023 May. PMID 36840361, Free PMC Article
  4. Specialized Cortex Glial Cells Accumulate Lipid Droplets in Drosophila melanogaster. Kis V, et al. PLoS One, 2015. PMID 26148013, Free PMC Article
  5. Loss of swiss cheese in Neurons Contributes to Neurodegeneration with Mitochondria Abnormalities, Reactive Oxygen Species Acceleration and Accumulation of Lipid Droplets in Drosophila Brain. Melentev PA, et al. Int J Mol Sci, 2021 Jul 31. PMID 34361042, Free PMC Article

See all (170) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle.
    Title: Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle.
  2. An RDH-Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase.
    Title: An RDH-Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase.
  3. Functional Characterization of Gomisin N in High-Fat-Induced Drosophila Obesity Models.
    Title: Functional Characterization of Gomisin N in High-Fat-Induced Drosophila Obesity Models.
  4. Lsd-2-knockdown up-regulated the expression of the dFoxO transcription target reaper, which constitutes a pro-apoptosis gene. This study provides the first evidence that Lsd-2-knockdown causes cell death mediated by dfoxO.
    Title: LSD-2 dysfunction induces dFoxO-dependent cell death in the wing of Drosophila melanogaster.
  5. that HDAC6 is associated physically with the chaperone protein dHsc4/Hsc70 to maintain the proteostasis of PLIN2
    Title: HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila.
  6. Perilipin homologus, LSD2 plays a role in sleep regulation and prevents learning impariment following sleep loss.
    Title: The perilipin homologue, lipid storage droplet 2, regulates sleep homeostasis and prevents learning impairments following sleep loss.
  7. Lsd-2 is expressed and controls lipid storage in wing imaginal discs.
    Title: Drosophila Lipid Storage Droplet 2 gene (Lsd-2) is expressed and controls lipid storage in wing imaginal discs.
  8. LSD2 regulates both lipid metabolism and transport along microtubules in embryos.
    Title: Regulation of lipid-droplet transport by the perilipin homolog LSD2.
  9. Lsd2 has an evolutionarily conserved function in lipid metabolism
    Title: Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism.
  10. Lsd2, one of only two PAT domain-encoding genes in the Drosophila genome acts in a Perilipin-like manner, suggesting that components regulating homeostasis of lipid-based energy storage at the lipid droplet membrane are evolutionarily conserved.
    Title: Control of fat storage by a Drosophila PAT domain protein.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid droplet formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid droplet organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid droplet transport along microtubule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid storage IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid transport IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of sequestering of triglyceride IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of sequestering of triglyceride IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sequestering of triglyceride IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lipid storage droplet-2
Names
CG9057-PA
CG9057-PB
CG9057-PD
CG9057-PE
CG9057-PF
Lipid-storage Droplet-2
Lsd-2-PA
Lsd-2-PB
Lsd-2-PD
Lsd-2-PE
Lsd-2-PF
Perilipin2
lipid storage droplet 2
lipid storage droplet 2 gene
lipid storage droplet protein 2
perilipin
perilipin-2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15069127..15076220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298333.1 → NP_001285262.1  lipid storage droplet-2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285262.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JKC1
    Conserved Domains (1) summary
    pfam03036
    Location:40 → 200
    Perilipin; Perilipin family

  2. NM_001042811.2 → NP_001036276.1  lipid storage droplet-2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036276.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHS7
    Conserved Domains (1) summary
    pfam03036
    Location:40 → 270
    Perilipin; Perilipin family

  3. NM_001042812.2 → NP_001036277.2  lipid storage droplet-2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036277.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHS6
    Conserved Domains (1) summary
    pfam03036
    Location:40 → 200
    Perilipin; Perilipin family

  4. NM_132768.3 → NP_572996.1  lipid storage droplet-2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572996.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VXY7
    Related
    FBpp0073784
    Conserved Domains (1) summary
    pfam03036
    Location:40 → 287
    Perilipin; Perilipin family

  5. NM_001298332.1 → NP_001285261.1  lipid storage droplet-2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285261.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JKC1
    Conserved Domains (1) summary
    pfam03036
    Location:40 → 200
    Perilipin; Perilipin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0KHS6 Q0KHS6
Q0KHS7 Q0KHS7
Q9VXY7.1 Q9VXY7
X2JKC1 X2JKC1

Gene LinkOut

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