gstm.1 glutathione S-transferase mu, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gstm.1provided by ZNC
Official Full Name: glutathione S-transferase mu, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030911-2
See related: Ensembl:ENSDARG00000042533 AllianceGenome:ZFIN:ZDB-GENE-030911-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gstm; GSTM1; cb760; zgc:66370; wu:fc26g06
Summary: Enables glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Is expressed in several structures, including alar plate midbrain region; brain; gill; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to several human genes including GSTM3 (glutathione S-transferase mu 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (25295234..25297928)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (25276095..25278789)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb72d11 (e-PCR)
- UniSTS:187411

fb72d11.x1 (e-PCR)
- UniSTS:191101

fc26g06.x1 (e-PCR)
- UniSTS:203902

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutathione S-transferase mu, tandem duplicate 1

Names: glutathione S-transferase M

NP_997841.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212676.1 → NP_997841.1 glutathione S-transferase mu, tandem duplicate 1

See identical proteins and their annotated locations for NP_997841.1

Status: PROVISIONAL

Source sequence(s)

BC057526

UniProtKB/TrEMBL

Q6PFJ6

Related

ENSDARP00000049792.6, ENSDART00000049793.8

Conserved Domains (3) summary

PTZ00057
Location:5 → 201

PTZ00057; glutathione s-transferase; Provisional

cd03209
Location:92 → 211

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:3 → 84

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...