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fstl1b follistatin-like 1b [ Danio rerio (zebrafish) ]

Gene ID: 324309, updated on 9-Dec-2024

Summary

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Official Symbol
fstl1bprovided by ZNC
Official Full Name
follistatin-like 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3029
See related
Ensembl:ENSDARG00000039576 AllianceGenome:ZFIN:ZDB-GENE-030131-3029
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa95c03; fc25c04; wu:fa95c03; wu:fc25c04
Summary
Predicted to enable calcium ion binding activity and heparin binding activity. Acts upstream of or within dorsal/ventral pattern formation; notochord cell differentiation; and regulation of BMP signaling pathway. Predicted to be active in extracellular region. Is expressed in several structures, including axis; central nervous system; fin; head mesenchyme; and mesoderm. Orthologous to human FSTL1 (follistatin like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See fstl1b in Genome Data Viewer
Location:
chromosome: 9
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (9735493..9842149, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (9757456..9864112, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 156 Neighboring gene leucine rich repeat containing 58b Neighboring gene uncharacterized LOC137496420 Neighboring gene transcription termination factor, RNA polymerase II Neighboring gene protein arginine methyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hypoxia induces myocardial regeneration in zebrafish. Jopling C, et al. Circulation, 2012 Dec 18. PMID 23151342
  2. Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration. Cao Y, et al. Development, 2022 Feb 15. PMID 35179181, Free PMC Article
  3. Expression profiling identifies novel Hh/Gli-regulated genes in developing zebrafish embryos. Bergeron SA, et al. Genomics, 2008 Feb. PMID 18055165, Free PMC Article
  4. Short- and long-range functions of Goosecoid in zebrafish axis formation are independent of Chordin, Noggin 1 and Follistatin-like 1b. Dixon Fox M, et al. Development, 2009 May. PMID 19369398
  5. BMP heterodimers signal via distinct type I receptor class functions. Tajer B, et al. Proc Natl Acad Sci U S A, 2021 Apr 13. PMID 33827919, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within notochord cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within notochord development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
follistatin-related protein 1b
Names
follistatin-like 2
fstl2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039621.1 → NP_001034710.1  follistatin-related protein 1b precursor

    See identical proteins and their annotated locations for NP_001034710.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ317971
    UniProtKB/TrEMBL
    A0A8M1N8A5, Q2PMI2
    Related
    ENSDARP00000105068.2, ENSDART00000121456.3
    Conserved Domains (4) summary
    smart00274
    Location:30 → 52
    FOLN; Follistatin-N-terminal domain-like
    cd00104
    Location:57 → 97
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam13499
    Location:148 → 218
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:148 → 218
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    9735493..9842149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009304495.4 → XP_009302770.1  follistatin-related protein 1b isoform X1

    UniProtKB/TrEMBL
    A0A8M3BCA5
    Conserved Domains (4) summary
    smart00274
    Location:29 → 51
    FOLN; Follistatin-N-terminal domain-like
    cd00104
    Location:56 → 96
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam13499
    Location:147 → 217
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:147 → 217
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein Strain
Heading Accession and Version

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