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CG14411 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32408, updated on 27-Dec-2024

Summary

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Official Symbol
CG14411provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030582
Locus tag
Dmel_CG14411
See related
AllianceGenome:FB:FBgn0030582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG14411; MTMR10/11/12
Summary
Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Involved in defense response to Gram-negative bacterium. Predicted to be active in cytoplasm and membrane. Is expressed in adult head. Orthologous to several human genes including MTMR10 (myotubularin related protein 10) and MTMR12 (myotubularin related protein 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG14411 in Genome Data Viewer
Location:
12F5-12F5; 1-49 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14832647..14836262)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14726680..14730295)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45522 Neighboring gene rutabaga Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutaredoxin 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myotubularin phosphatases: policing 3-phosphoinositides. Robinson FL, et al. Trends Cell Biol, 2006 Aug. PMID 16828287
  2. Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. Jean S, et al. Mol Biol Cell, 2012 Jul. PMID 22648168, Free PMC Article
  3. Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection. Berkey CD, et al. Cell Microbiol, 2009 Mar. PMID 19046341, Free PMC Article
  4. Expansion and evolution of insect GMC oxidoreductases. Iida K, et al. BMC Evol Biol, 2007 May 11. PMID 17498303, Free PMC Article
  5. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. Allen EA, et al. J Cell Biol, 2020 Nov 2. PMID 32915229, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables phosphatase activity IKR
Inferred from Key Residues
more info
 PubMed 
enables phosphatidylinositol-3-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables protein tyrosine phosphatase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG14411-PA
CG14411-PB
CG14411-PC
CG14411-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    14832647..14836262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132744.3 → NP_572972.1  uncharacterized protein Dmel_CG14411, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572972.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2XY44, Q9VY15
    Related
    FBpp0073763
    Conserved Domains (3) summary
    pfam12578
    Location:666 → 732
    3-PAP; Myotubularin-associated protein
    cl17171
    Location:114 → 225
    PH-like; Pleckstrin homology-like domain
    cl21483
    Location:400 → 587
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. NM_206713.3 → NP_996436.1  uncharacterized protein Dmel_CG14411, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996436.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2XY44, Q9VY15
    Conserved Domains (3) summary
    pfam12578
    Location:666 → 732
    3-PAP; Myotubularin-associated protein
    cl17171
    Location:114 → 225
    PH-like; Pleckstrin homology-like domain
    cl21483
    Location:400 → 587
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  3. NM_001169285.2 → NP_001162756.1  uncharacterized protein Dmel_CG14411, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162756.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2XY44, Q9VY15
    Conserved Domains (3) summary
    pfam12578
    Location:666 → 732
    3-PAP; Myotubularin-associated protein
    cl17171
    Location:114 → 225
    PH-like; Pleckstrin homology-like domain
    cl21483
    Location:400 → 587
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  4. NM_001169286.2 → NP_001162757.1  uncharacterized protein Dmel_CG14411, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162757.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2XY44, Q9VY15
    Conserved Domains (3) summary
    pfam12578
    Location:666 → 732
    3-PAP; Myotubularin-associated protein
    cl17171
    Location:114 → 225
    PH-like; Pleckstrin homology-like domain
    cl21483
    Location:400 → 587
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2XY44 Q2XY44
Q8SWS5 Q8SWS5
Q9VY15 Q9VY15

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